Seeking signatures of reinforcement at the genetic level: a hitchhiking mapping and candidate gene approach in the house mouse.
Détails
ID Serval
serval:BIB_5B9352FD1318
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Seeking signatures of reinforcement at the genetic level: a hitchhiking mapping and candidate gene approach in the house mouse.
Périodique
Molecular ecology
ISSN
1365-294X (Electronic)
ISSN-L
0962-1083
Statut éditorial
Publié
Date de publication
08/2015
Peer-reviewed
Oui
Volume
24
Numéro
16
Pages
4222-4237
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Reinforcement is the process by which prezygotic isolation is strengthened as a response to selection against hybridization. Most empirical support for reinforcement comes from the observation of its possible phenotypic signature: an accentuated degree of prezygotic isolation in the hybrid zone as compared to allopatry. Here, we implemented a novel approach to this question by seeking for the signature of reinforcement at the genetic level. In the house mouse, selection against hybrids and enhanced olfactory-based assortative mate preferences are observed in a hybrid zone between the two European subspecies Mus musculus musculus and M. m. domesticus, suggesting a possible recent reinforcement event. To test for the genetic signature of reinforcing selection and identify genes involved in sexual isolation, we adopted a hitchhiking mapping approach targeting genomic regions containing candidate genes for assortative mating in mice. We densely scanned these genomic regions in hybrid zone and allopatric samples using a large number of fast evolving microsatellite loci that allow the detection of recent selection events. We found a handful of loci showing the expected pattern of significant reduction in variability in populations close to the hybrid zone, showing assortative odour preference in mate choice experiments as compared to populations further away and displaying no such preference. These loci lie close to genes that we pinpoint as testable candidates for further investigation.
Mots-clé
Animals, Austria, Denmark, Female, Genetics, Population, Genome, Genomics, Hybridization, Genetic, Male, Mating Preference, Animal, Mice/genetics, Microsatellite Repeats, Odorants, Phenotype, Selection, Genetic, Sequence Analysis, DNA, genomics, hybrid zone, major urinary protein, selective sweep, speciation, vomeronasal receptor
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/07/2015 8:48
Dernière modification de la notice
03/05/2024 10:19