Actin-related proteins in the nucleus: life beyond chromatin remodelers.
Détails
ID Serval
serval:BIB_5B619E590F9A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Actin-related proteins in the nucleus: life beyond chromatin remodelers.
Périodique
Current Opinion in Cell Biology
ISSN
1879-0410 (Electronic)
ISSN-L
0955-0674
Statut éditorial
Publié
Date de publication
2010
Volume
22
Numéro
3
Pages
383-391
Langue
anglais
Résumé
Since their discovery in the mid-1990s, nuclear actin-related proteins (ARPs) have gained attention for their roles as structural components of ATP-dependent chromatin-remodeling complexes. These remodelers can move nucleosomes along the DNA, evict them from chromatin, and exchange histone variants to alter chromatin states locally. Chromatin-remodeling facilitates DNA-templated processes such as transcription regulation, DNA replication, and repair. Consistent with a role for ARPs in shaping chromatin structure, recent genetic studies show that they affect developmental and cell-type specific transcriptional programming. Here, we focus on recent results that suggest a specific contribution of ARPs to long-range interactions in the nucleus, and review evidence indicating that some ARPs may act independently of chromatin-remodeling machines.
Mots-clé
Actins/metabolism, Animals, Cell Nucleus/metabolism, Chromatin Assembly and Disassembly, Humans, Models, Biological, Nuclear Proteins/chemistry, Nuclear Proteins/metabolism, Ribosomes/genetics
Pubmed
Web of science
Création de la notice
12/02/2014 16:16
Dernière modification de la notice
20/08/2019 14:14