Plasma angiotensin II and the antihypertensive action of angiotensin-converting enzyme inhibition

Détails

ID Serval
serval:BIB_5B472C9031F3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Plasma angiotensin II and the antihypertensive action of angiotensin-converting enzyme inhibition
Périodique
American Journal of Hypertension
Auteur(s)
Nussberger  J., Waeber  B., Brunner  H. R.
ISSN
0895-7061 (Print)
Statut éditorial
Publié
Date de publication
04/1989
Volume
2
Numéro
4
Pages
286-93
Notes
Journal Article
Review --- Old month value: Apr
Résumé
The measurement of immunoreactive "angiotensin II" in plasma cannot provide an accurate reflection of the efficacy of angiotensin-converting enzyme (ACE) inhibition because different angiotensin fragments interfere in all radioimmunoassays available so far. More complex methods are necessary in order to measure specifically angiotensin-(1-8)octapeptide. With such methodology it can be shown that no tolerance develops to the angiotensin II-reducing effect of ACE inhibitors after prolonged administration. Marked reduction of angiotensin II levels can be shown even in patients with primary aldosteronism. At peak blockade, the level of plasma angiotensin II is still related to circulating active renin and angiotensin I. Accordingly, because ACE inhibitors raise circulating angiotensin I in a dose-dependent fashion, this should be taken into account when dosing ACE inhibitors. The hypothesis that tissue renin-angiotensin systems play an important independent role in determining vasomotor tone is very interesting. However, any discussion on whether tissue or plasma renin determines the pharmacological effect of ACE inhibitors should be based on the simultaneous measurement of true angiotensin II in tissue and plasma under steady-state conditions.
Mots-clé
Angiotensin II/*blood/physiology Angiotensin-Converting Enzyme Inhibitors/*pharmacology *Antihypertensive Agents Blood Pressure/drug effects Humans Hyperaldosteronism/blood Renin/antagonists & inhibitors Renin-Angiotensin System
Pubmed
Web of science
Création de la notice
05/03/2008 16:41
Dernière modification de la notice
20/08/2019 14:14
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