In vivo phosphorus 31 magnetic resonance spectroscopy of human uveal melanomas and other intraocular tumors

Détails

ID Serval
serval:BIB_5B46BA322FDA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
In vivo phosphorus 31 magnetic resonance spectroscopy of human uveal melanomas and other intraocular tumors
Périodique
American Journal of Ophthalmology
Auteur(s)
De Potter  P., von Weymarn  C., Zografos  L.
ISSN
0002-9394 (Print)
Statut éditorial
Publié
Date de publication
03/1991
Volume
111
Numéro
3
Pages
276-88
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Résumé
We studied the feasibility of using the surface coil probe technique for the noninvasive in vivo study of ocular tumors by phosphorus 31 magnetic resonance spectroscopy. The characteristic organophosphate metabolites of suspected uveal melanomas before proton beam irradiation were determined qualitatively by phosphorus 31 magnetic resonance spectroscopy in vivo using a three-turn surface coil. Spectra of choroidal hemangioma, osteoma, and metastasis were also obtained in vivo and compared with those of uveal melanomas. Analysis of spectra performed at 1.5 T showed significant peaks of phosphomonoesters, inorganic phosphate, phosphodiesters, phosphocreatine, and adenosine 5'-triphosphates. The unusually high concentration of phosphodiesters may be considered as a marker for uveal melanomas and other choroidal tumors. By analyzing the ratio of phosphocreatine to phosphodiesters spectral area values, we interpreted qualitatively spectra of intraocular tumors to differentiate malignant tumors from benign lesions. Nevertheless, the main limitation of interpreting the spectra was their contamination by signals from surrounding tissues.
Mots-clé
Adult Aged Eye/metabolism Eye Neoplasms/*metabolism Female Humans *Magnetic Resonance Imaging Male Melanoma/*metabolism/secondary Middle Aged Organophosphorus Compounds/metabolism Phosphorus Isotopes Tumor Markers, Biological/metabolism Uveal Neoplasms/*metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 13:10
Dernière modification de la notice
20/08/2019 14:14
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