Bile duct carcinoid tumors: an uncommon disease but with a good prognosis?

Détails

ID Serval
serval:BIB_5B204746E09E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Bile duct carcinoid tumors: an uncommon disease but with a good prognosis?
Périodique
Hepato-gastroenterology
Auteur⸱e⸱s
Hubert C., Sempoux C., Berquin A., Deprez P., Jamar F., Gigot J.F.
ISSN
0172-6390 (Print)
ISSN-L
0172-6390
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
52
Numéro
64
Pages
1042-1047
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Review Publication Status: ppublish
Résumé
UNLABELLED: Carcinoid tumors of the biliary tract are exceedingly uncommon. We report 3 cases of primary carcinoid tumors of the biliary tract, which are compared to the reported patients in the literature and to the patients' data with other types of biliary malignancies in our experience.
SETTING: Retrospective analysis in a single academic institution. From a consecutive series of 79 resected tumors of the biliary tract between 1979 and 2002, 3 patients were found to suffer from primary carcinoid tumors (3.8%). There were 2 males and one female patient, with a mean age of 56 years old (range: 46-73), younger than other malignant biliary cancer cases. Clinical presentation included obstructive jaundice in 2 patients. There were no signs of diarrhea or carcinoid syndrome. Location of the tumor included the extrahepatic bile duct in all patients. Two of these patients had a polypoid tumor obstructing the bile duct. The disease was localized in 2 patients, but with liver metastases in the remaining patient. Final diagnosis was achieved on final pathological examination in 2 patients, but preoperative endoscopic biopsies allowed correct diagnosis of nature and tumor staging by octreotide scintigraphy in one patient. Radical resection was achieved in 2 patients with long-term cure at 8.5 and 9.5 years, respectively. A high-risk patient with a small residual liver metastasis after resection is still alive and disease-free under LAR Octreotide SC administration at 17 months postoperatively. The median survival time for patients suffering from carcinoid tumors was 102 months while it was 33 months for patients suffering from cholangiocarcinomas in our experience. Carcinoid tumors of the biliary tract are exceedingly rare. Preoperative diagnosis is uncommon but possible by endoscopic biopsies. Radical resection seems to be associated with a longer survival than classical cholangiocarcinoma.
Mots-clé
Aged, Bile Duct Neoplasms/diagnosis, Bile Duct Neoplasms/mortality, Bile Ducts, Extrahepatic/surgery, Carcinoid Tumor/diagnosis, Carcinoid Tumor/mortality, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Survival Rate
Pubmed
Web of science
Création de la notice
20/10/2016 17:16
Dernière modification de la notice
20/08/2019 15:14
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