Leptin as a Potential Regulator of FGF21.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_5AB6975674ED
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Leptin as a Potential Regulator of FGF21.
Périodique
Cellular Physiology and Biochemistry
Auteur(s)
Asrih M., Veyrat-Durebex C., Poher A.L., Lyautey J., Rohner-Jeanrenaud F., Jornayvaz F.R.
ISSN
1421-9778 (Electronic)
ISSN-L
1015-8987
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
38
Numéro
3
Pages
1218-1225
Langue
anglais
Résumé
BACKGROUND/AIMS: Fibroblast growth factor 21 (FGF21), a potent metabolic regulator, has been shown to improve insulin sensitivity in animal models of insulin resistance. Several studies have focused on identifying mediators of FGF21 effects. However, the identification of factors involved in FGF21 regulation is far from complete. As leptin is a potent metabolic modulator as well, we aimed at characterizing whether leptin may regulate FGF21.
METHODS: We investigated a potential regulation of FGF21 by leptin in vivo in Wistar rats and in vitro using human derived hepatocarcinoma HepG2 cells. This model was chosen as the liver is considered the main FGF21 expression site.
RESULTS: We found that leptin injections increased plasma FGF21 levels in adult Wistar rats. This was confirmed in vitro, as leptin increased FGF21 expression in HepG2 cells. We also showed that the leptin effect on FGF21 expression was mediated by STAT3 activation in HepG2 cells.
CONCLUSION: New findings regarding a leptin-STAT3-FGF21 axis were provided in this study, although investigating the exact mechanisms linking leptin and FGF21 are still needed. These results are of great interest in the context of identifying potential new clinical approaches to treat metabolic diseases associated with insulin resistance, such as obesity and type 2 diabetes.
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/04/2016 17:59
Dernière modification de la notice
20/08/2019 15:13
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