The role of gastric lipolysis on fat absorption and bile acid metabolism in the rat

Détails

ID Serval
serval:BIB_5A976114F72F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The role of gastric lipolysis on fat absorption and bile acid metabolism in the rat
Périodique
Lipids
Auteur⸱e⸱s
Roy  C. C., Roulet  M., Lefebvre  D., Chartrand  L., Lepage  G., Fournier  L. A.
ISSN
0024-4201 (Print)
Statut éditorial
Publié
Date de publication
09/1979
Volume
14
Numéro
9
Pages
811-5
Notes
Journal Article --- Old month value: Sep
Résumé
In vivo studies were carried out in young Sprague-Dawley rats to examine the role of gastric lipolysis on fat absorption and bile acid metabolism. When fed by gastric perfusion 5 times (corn oil, 4 g/day) their usual dietary intake of fat, rats deprived of lingual lipase by the creation of an esophageal fistula had a significant degree of fat and bile acid malabsorption as well as a shortened bile acid half-life when compared to animals with a gastrostomy. The % fat absorption, bile acid loss and bile acid pool were normal in 2 groups of esophageal fistula rats fed the same quantity of corn oil or twice (8 g/day) that amount as a fine emulsion. In view of a negligible gastric lipase activity in animals with an esophageal fistula and of decreased hydrolysis of a triglyceride test meal, these data suggest that gastric lipolysis is of physiological importance in situations where lipolytic mechanisms are stressed by a large fat intkae. Its principal role is to potentiate intestinal lipolysis by facilitating the emulsification of dietary lipids through its formed products and, therefore, the contact of pancreatic lipase with its substrates.
Mots-clé
Animals Bile Acids and Salts/*metabolism *Dietary Fats Enterohepatic Circulation Gastric Mucosa/*metabolism Half-Life *Intestinal Absorption Kinetics Lipase/metabolism Lipid Metabolism *Lipid Mobilization Male Rats
Pubmed
Web of science
Création de la notice
24/01/2008 21:33
Dernière modification de la notice
20/08/2019 15:13
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