New branches in the degradation pathway of monochlorocatechols by Aspergillus nidulans: a metabolomics analysis.

Détails

ID Serval
serval:BIB_5A8F698BBC6F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
New branches in the degradation pathway of monochlorocatechols by Aspergillus nidulans: a metabolomics analysis.
Périodique
Journal of hazardous materials
Auteur⸱e⸱s
Martins T.M., Núñez O., Gallart-Ayala H., Leitão M.C., Galceran M.T., Silva Pereira C.
ISSN
1873-3336 (Electronic)
ISSN-L
0304-3894
Statut éditorial
Publié
Date de publication
15/03/2014
Volume
268
Pages
264-272
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
A collective view of the degradation of monochlorocatechols in fungi is yet to be attained, though these compounds are recognised as key degradation intermediates of numerous chlorinated aromatic hydrocarbons, including monochlorophenols. In the present contribution we have analysed the degradation pathways of monochlorophenols in Aspergillus nidulans using essentially metabolomics. Degradation intermediates herein identified included those commonly reported (e.g. 3-chloro-cis,cis-muconate) but also compounds never reported before in fungi revealing for 4-chlorocatechol and for 3-chlorocatechol unknown degradation paths yielding 3-chlorodienelactone and catechol, respectively. A different 3-chlorocatechol degradation path led to accumulation of 2-chloromuconates (a potential dead-end), notwithstanding preliminary evidence of chloromuconolactones and protoanemonin simultaneous formation. In addition, some transformation intermediates, of which sulfate conjugates of mono-chlorophenols/chlorocatechols were the most common, were also identified. This study provides critical information for understanding the role of fungi in the degradation of chlorinated aromatic hydrocarbons; furthering their utility in the development of innovative bioremediation strategies.

Mots-clé
Aspergillus nidulans/growth & development, Aspergillus nidulans/metabolism, Biodegradation, Environmental, Biotransformation, Catechols/chemistry, Catechols/isolation & purification, Catechols/metabolism, Environmental Pollutants/chemistry, Environmental Pollutants/isolation & purification, Environmental Pollutants/metabolism, Hydrocarbons, Chlorinated/chemistry, Hydrocarbons, Chlorinated/isolation & purification, Hydrocarbons, Chlorinated/metabolism, Metabolic Networks and Pathways, Metabolomics, Molecular Structure, Mycelium/growth & development, Mycelium/metabolism
Pubmed
Création de la notice
19/04/2017 17:10
Dernière modification de la notice
21/08/2019 5:34
Données d'usage