Effects of propranolol on resting metabolic rate after severe head injury.

Détails

ID Serval
serval:BIB_5A758CC4B883
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of propranolol on resting metabolic rate after severe head injury.
Périodique
Critical Care Medicine
Auteur(s)
Chioléro R.L., Breitenstein E., Thorin D., Christin L., de Tribolet N., Freeman J., Jéquier E., Schutz Y.
ISSN
0090-3493 (Print)
ISSN-L
0090-3493
Statut éditorial
Publié
Date de publication
1989
Volume
17
Numéro
4
Pages
328-334
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Postabsorptive resting metabolic rate (RMR), measured by indirect calorimetry, and the effect of iv propranolol administration were studied in 12 nonseptic patients with severe head injury by means of indirect calorimetry. Before propranolol RMR was moderately increased (126 +/- 10.4% of predicted values) whereas urinary excretion of catecholamines was markedly elevated (p less than .01 vs. normal values). RMR was significantly correlated with both resting heart rate (HR) (r = .72, p less than .01) and 24-h urinary N excretion (r = .85, p less than .001). The administration of iv propranolol (0.1 mg/kg) produced a rapid decrease in HR (-10 +/- 4%, p less than .001) and in RMR (-6.1 +/- 2.3%, p less than .001). Further administration of propranolol produced no additional reduction in either HR or RMR. We conclude that severely head-injured patients are moderately hypermetabolic in resting and postabsorptive conditions, and that acute iv propranolol administration induces a reduction of about one quarter of the resting hypermetabolism.
Mots-clé
Adolescent, Adult, Basal Metabolism/drug effects, Calorimetry, Catecholamines/urine, Child, Craniocerebral Trauma/metabolism, Female, Heart Rate, Humans, Infusions, Intravenous, Male, Middle Aged, Propranolol/pharmacology
Pubmed
Web of science
Création de la notice
21/01/2008 14:08
Dernière modification de la notice
20/08/2019 15:13
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