Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons.

Détails

ID Serval
serval:BIB_5A704B47AA29
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons.
Périodique
Nature neuroscience
Auteur⸱e⸱s
Tang Y., Benusiglio D., Lefevre A., Hilfiger L., Althammer F., Bludau A., Hagiwara D., Baudon A., Darbon P., Schimmer J., Kirchner M.K., Roy R.K., Wang S., Eliava M., Wagner S., Oberhuber M., Conzelmann K.K., Schwarz M., Stern J.E., Leng G., Neumann I.D., Charlet A., Grinevich V.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
09/2020
Peer-reviewed
Oui
Volume
23
Numéro
9
Pages
1125-1137
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Oxytocin (OT) is a great facilitator of social life but, although its effects on socially relevant brain regions have been extensively studied, OT neuron activity during actual social interactions remains unexplored. Most OT neurons are magnocellular neurons, which simultaneously project to the pituitary and forebrain regions involved in social behaviors. In the present study, we show that a much smaller population of OT neurons, parvocellular neurons that do not project to the pituitary but synapse onto magnocellular neurons, is preferentially activated by somatosensory stimuli. This activation is transmitted to the larger population of magnocellular neurons, which consequently show coordinated increases in their activity during social interactions between virgin female rats. Selectively activating these parvocellular neurons promotes social motivation, whereas inhibiting them reduces social interactions. Thus, parvocellular OT neurons receive particular inputs to control social behavior by coordinating the responses of the much larger population of magnocellular OT neurons.
Mots-clé
Animals, Behavior, Animal/physiology, Female, Neurons/physiology, Oxytocin/metabolism, Paraventricular Hypothalamic Nucleus/physiology, Rats, Rats, Wistar, Social Behavior, Touch, Touch Perception/physiology
Pubmed
Web of science
Création de la notice
11/08/2020 9:49
Dernière modification de la notice
12/04/2024 11:08
Données d'usage