On the significance of CD8 alpha alpha expression for T cell memory.

Détails

ID Serval
serval:BIB_5A59F43CAC2B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
On the significance of CD8 alpha alpha expression for T cell memory.
Périodique
European Journal of Immunology
Auteur(s)
Romero P., Cerottini J.C., Luescher I.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
35
Numéro
11
Pages
3092-3094
Langue
anglais
Résumé
Longitudinal studies on the kinetics of viral antigen specific CD8 T cell responses have led to a model whereby a relatively small subset of the primary effector CD8 T cells expanding after the first week of acute viral infection initiate a program of cell survival and differentiation into long lived memory T cells. These T cells are then critical for maintaining protective immunity to subsequent viral infection. Recent observations, using fluorescent tetramers of the MHC class Ib molecule TL, link transient expression of CD8alphaalpha homodimers on expanding primary effector CD8 T cells to the generation of memory cells. At present it is controversial what the role of CD8alphaalpha is in the generation of memory CD8 T cells. The involvement of the high affinity CD8alphaalpha ligand, the TL molecule, is not understood either. However, evidence from two viral infection models in mice, including one paper in this issue of the European Journal of Immunology, suggest a role for CD8alphaalpha in this process and call for additional research focus into these issues.
Mots-clé
Antigens, CD8/biosynthesis, Antigens, CD8/physiology, Humans, Immunologic Memory/immunology, T-Lymphocytes/immunology, T-Lymphocytes/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:20
Dernière modification de la notice
20/08/2019 15:13
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