The role of Helicobacter pylori in primary gastric MALT lymphoma

Détails

ID Serval
serval:BIB_5A38AC977C96
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The role of Helicobacter pylori in primary gastric MALT lymphoma
Périodique
Histopathology
Auteur⸱e⸱s
Bouzourene  H., Haefliger  T., Delacretaz  F., Saraga  E.
ISSN
0309-0167 (Print)
Statut éditorial
Publié
Date de publication
1999
Volume
34
Numéro
2
Pages
118-123
Notes
PT - Journal Article
Résumé
AIMS: Helicobacter pylori has been claimed to be an important aetiological factor which raises the risk of mucosa-associated tissue lymphoid (MALT) lymphoma. However, some studies on gastric MALT lymphoma revealed a low rate of H. pylori infection suggesting that not all gastric lymphomas are related to H. pylori infection. The aim of this study was to verify the H. pylori infection frequency in a series of patients with primary gastric MALT lymphomas and to examine the relationship between H. pylori and the pathological features of those lymphomas. METHODS AND RESULTS: Thirty-one cases of resected gastric lymphoma were analysed: 10 cases (32%) were low-grade MALT lymphomas and 21 cases (68%) were high-grade MALT lymphomas. Helicobacter pylori was found in only 18 of 31 (58%) cases. Helicobacter pylori infection was significantly correlated with the grade and depth of invasion of MALT lymphoma since 63% of superficial low-grade MALT lymphomas were positive for H. pylori compared with 38% of advanced high-grade MALT lymphomas (P = 0.02). CONCLUSION: We confirmed the relationship between H. pylori infection and a subset of gastric MALT lymphoma. Our results also showed that not all low- and high-grade gastric MALT lymphomas are H. pylori-dependent. This suggests that H. pylori infection may play a promoter role in the development of MALT lymphoma, but its presence is not mandatory for the progression of the lymphoma in view of its low frequency in advanced high-grade MALT lymphoma
Mots-clé
Adult/Aged/Aged,80 and over/Female/Helicobacter Infections/epidemiology/Helicobacter pylori/pathogenicity/Humans/Immunohistochemistry/Lymphoma,Mucosa-Associated Lymphoid Tissue/microbiology/Pathology/Male/Middle Aged/Stomach Neoplasms
Pubmed
Web of science
Création de la notice
29/01/2008 18:35
Dernière modification de la notice
20/08/2019 14:13
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