Antibiotic susceptibility of Estrella lausannensis, a potential emerging pathogen.

Détails

ID Serval
serval:BIB_5A37BDB79F6E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antibiotic susceptibility of Estrella lausannensis, a potential emerging pathogen.
Périodique
Microbes and Infection / Institut Pasteur
Auteur(s)
de Barsy M., Bottinelli L., Greub G.
ISSN
1769-714X (Electronic)
ISSN-L
1286-4579
Statut éditorial
Publié
Date de publication
2014
Volume
16
Numéro
9
Pages
746-754
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Estrella lausannensis is a new Chlamydia-related bacterium, belonging to the Criblamydiaceae family. As suggested by its species name, this bacterium harbors a peculiar star shape. E. lausannensis is able to infect a wide range of amoebal, fish and mammalian cell lines. Moreover, seroprevalence of 2.9% was reported in children and in women with tubal pathology, showing that humans are commonly exposed to this recently discovered strict intracellular bacteria considered as a potential pathogen. Antibiotic susceptibility was determined using two approaches: qPCR and cellular mortality assay. Antibiotics classically used against intracellular bacteria were tested, including β-lactams, fluoroquinolones, cyclines and macrolides. We showed that E. lausannensis is resistant to β-lactams and fluoroquinolones, and sensitive to cyclines. Interestingly, E. lausannensis is slightly resistant to azithromycin with a MIC of 2 μg/ml, which is 10 fold higher compared to Waddlia chondrophila and Parachlamydia acanthamoebae MIC's. A single A2059C mutation in 23S rRNA gene could be responsible for this unexpected resistance.
Pubmed
Web of science
Création de la notice
13/02/2015 18:43
Dernière modification de la notice
20/08/2019 15:13
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