Small cell (neuroendocrine) carcinoma of the prostate: etiology, diagnosis, prognosis, and therapeutic implications--a retrospective study of 30 patients from the rare cancer network.

Détails

ID Serval
serval:BIB_59D8B6B3E851
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Small cell (neuroendocrine) carcinoma of the prostate: etiology, diagnosis, prognosis, and therapeutic implications--a retrospective study of 30 patients from the rare cancer network.
Périodique
American Journal of the Medical Sciences
Auteur⸱e⸱s
Stein M.E., Bernstein Z., Abacioglu U., Sengoz M., Miller R.C., Meirovitz A., Zouhair A., Freixa S.V., Poortmans P.H., Ash R., Kuten A.
ISSN
0002-9629
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
336
Numéro
6
Pages
478-488
Langue
anglais
Résumé
Within the framework of the Rare Cancer Network Study, we examined 30 patients suffering from small cell neuroendocrine prostate cancer, either in an early/localized or an advanced/metastatic stage. Patients were treated with cisplatin-based chemotherapy, with or without pelvic radiotherapy. Two patients with early disease achieved complete remission for a duration of 19 and 22 months. Three patients with advanced disease achieved complete remission for 6, 7, and 54 months, respectively. Twenty-five patients succumbed to massive local and/or distant failure. No patient presented with brain metastases as the initial site of relapse. Small cell neuroendocrine prostate carcinoma is a very aggressive disease with a poor prognosis, even in its localized form. Despite initial response, the common cisplatin-based chemotherapy plus radiotherapy failed to improve outcome markedly. Improvement will come from understanding the biology of the disease and integrating new targeted therapies into the treatment of this rare and aggressive tumor.
Mots-clé
Adult, Aged, Aged, 80 and over, Carcinoma, Small Cell/etiology, Carcinoma, Small Cell/pathology, Diagnosis, Differential, Humans, Male, Middle Aged, Neoplasm Metastasis, Prognosis, Prostatic Neoplasms/etiology, Prostatic Neoplasms/pathology, Retrospective Studies
Pubmed
Web of science
Création de la notice
15/10/2009 8:38
Dernière modification de la notice
20/08/2019 14:13
Données d'usage