Carcinoembryonic antigen and related glycoproteins in psoriasis

Détails

ID Serval
serval:BIB_59D116A6932F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Carcinoembryonic antigen and related glycoproteins in psoriasis
Périodique
Pathobiology
Auteur(s)
Hagemeier  H. H., Bhardwaj  R., Grunert  F., Buchegger  F., Goerdt  S., von Kleist  S., Sorg  C.
ISSN
1015-2008 (Print)
Statut éditorial
Publié
Date de publication
1993
Volume
61
Numéro
1
Pages
19-24
Notes
Comparative Study
Journal Article
Résumé
Psoriasis is a benign but hyperproliferative skin disease. Psoriatic basal cells show a phenotype similar to that of normal skin, while psoriatic suprabasal cells exhibit a qualitatively altered keratinization pathway, resulting in the absence of the granular layer. These cells further show an abnormal expression of cellular differentiation antigens, which does not lead to tumor development. This immunohistological study demonstrates the appearance of carcinoembryonic antigen (CEA) in psoriatic suprabasal cells below the parakeratotic layer, while other markers such as CEA-related antigens, the nonspecific cross-reacting antigens and alpha-fetoprotein are not expressed. CEA is absent in normal skin, lichen planus, ichthyosis vulgaris and allergic dermatitis. Our data support the notion that dedifferentiation of psoriatic suprabasal keratinocytes is due to the reactivation of early developmental patterns of differentiation in this disease.
Mots-clé
Antibodies, Monoclonal Biopsy Carcinoembryonic Antigen/*analysis Cyclosporine/therapeutic use Endothelium/pathology Humans Immunohistochemistry PUVA Therapy Psoriasis/drug therapy/*pathology Reference Values Skin/cytology/*pathology Skin Diseases/pathology Sweat Glands/pathology
Pubmed
Web of science
Création de la notice
25/01/2008 12:28
Dernière modification de la notice
20/08/2019 15:13
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