Necrotic cell death in Caenorhabditis elegans.

Détails

ID Serval
serval:BIB_59AED9035B70
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Necrotic cell death in Caenorhabditis elegans.
Périodique
Methods in enzymology
Auteur⸱e⸱s
Nikoletopoulou V., Tavernarakis N.
ISSN
1557-7988 (Electronic)
ISSN-L
0076-6879
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
545
Pages
127-155
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Similar to other organisms, necrotic cell death in the nematode Caenorhabditis elegans is manifested as the catastrophic collapse of cellular homeostasis, in response to overwhelming stress that is inflicted either in the form of extreme environmental stimuli or by intrinsic insults such as the expression of proteins carrying deleterious mutations. Remarkably, necrotic cell death in C. elegans and pathological cell death in humans share multiple fundamental features and mechanistic aspects. Therefore, mechanisms mediating necrosis are also conserved across the evolutionary spectrum and render the worm a versatile tool, with the capacity to facilitate studies of human pathologies. Here, we overview necrotic paradigms that have been characterized in the nematode and outline the cellular and molecular mechanisms that mediate this mode of cell demise. In addition, we discuss experimental approaches that utilize C. elegans to elucidate the molecular underpinnings of devastating human disorders that entail necrosis.
Mots-clé
Animals, Apoptosis/genetics, Autophagy/genetics, Caenorhabditis elegans/genetics, Endocytosis/genetics, Gene Expression Regulation, Heat-Shock Response/genetics, Humans, Necrosis/genetics, Neurons/metabolism, Neurons/physiology, Apoptosis, Autophagy, Calpain, Cathepsin, Cell death, Endocytosis, Excitotoxicity, Heat shock, Heat stroke, Necrosis, Neurodegeneration, Stress
Pubmed
Web of science
Création de la notice
04/06/2024 11:00
Dernière modification de la notice
05/06/2024 9:05
Données d'usage