Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study.

Détails

ID Serval
serval:BIB_5946A6EFA04D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study.
Périodique
Nephrology, dialysis, transplantation
Auteur(s)
Vychytil A., Remón C., Michel C., Williams P., Rodríguez-Carmona A., Marrón B., Vonesh E., van der Heyden S., Divino Filho J.C.
Collaborateur(s)
Extraneal Peritonitis Study Group
Contributeur(s)
Carmona A.R., Fontán M.P., Rubio M.A., Gilsanz G.del P., Vychytil A., Dittrich E., Lilaj T., Diaz N.V., Steiger J., Mayr M., Goffin E., Michel C., Azeroual L., Hufnagel G., Pagniez D., Boulanger E., Moranne C., de Sequera P., Benito J., Verger C., Rodríguez C.R., Ganga P.Q., Marenco M.T., Roob J., Enzinger G., Heibel F., Bencheikh L., Tomero J.A., Cirugeda A., Erauzkin G.G., Rivera M.T., Cañamas T.T., Williams P.F., Genestier S., Caillette-Beaudoin A., Denicola C., Fusshoeller A., Farokhzad F., Gallar P., Marcos O.O., Villarreal I.R., Rivault O., Gomez J.M., Durand Y., Burnier M., Halabi G., Meier P., Nseir G., Phan O., Zellweger M., Marangon N., Martin P.Y., Triverio P.A., Issad B.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Statut éditorial
Publié
Date de publication
11/2008
Peer-reviewed
Oui
Volume
23
Numéro
11
Pages
3711-3719
Langue
anglais
Notes
Publication types: Controlled Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Icodextrin is a glucose polymer derived by hydrolysis of cornstarch. The different biocompatibility profile of icodextrin-containing peritoneal dialysis (PD) solutions may have a positive influence on peritoneal host defence. Furthermore, cases of sterile peritonitis potentially associated with icodextrin have been reported.
The primary objective of this multicentre, longitudinal, observational, non-interventional, prospective cohort study, which included 722 PD patients, was to evaluate the incidence of overall peritonitis in patients treated with icodextrin-containing PD solutions (Extraneal) used during one long-dwell exchange/day compared with those treated with non-icodextrin-containing PD solutions. The secondary objective was to determine if culture-negative peritonitis rates differed between patients treated with icodextrin from two independent manufacturers. All peritonitis episodes were assessed by a Steering Committee in a blind manner.
There was no significant difference between icodextrin-treated and control patients in the adjusted overall, culture-positive or culture-negative peritonitis rates. When stratified by the icodextrin supplier, there was no significant difference in the adjusted rate of culture-negative peritonitis episodes between groups.
Subjects receiving icodextrin as part of their PD regimen experienced neither a higher rate of culture-negative peritonitis nor a lower rate of infectious peritonitis compared with non-icodextrin users. There was no significant influence of the icodextrin raw material supplier on peritonitis rates.

Mots-clé
Adult, Aged, Chronic Disease, Cohort Studies, Dialysis Solutions/therapeutic use, Europe, Female, Glucans/therapeutic use, Glucose/therapeutic use, Humans, Kidney Diseases/therapy, Longitudinal Studies, Male, Middle Aged, Peritoneal Dialysis, Peritonitis/epidemiology, Peritonitis/prevention & control, Prevalence, Prospective Studies, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/11/2017 13:00
Dernière modification de la notice
20/08/2019 15:12
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