Humoral and cell-mediated immunity to the Plasmodium falciparum ring-infected erythrocyte surface antigen in an adult population exposed to highly endemic malaria

Détails

ID Serval
serval:BIB_590448E0F142
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Humoral and cell-mediated immunity to the Plasmodium falciparum ring-infected erythrocyte surface antigen in an adult population exposed to highly endemic malaria
Périodique
Infection and Immunity
Auteur(s)
Beck  H. P., Felger  I., Genton  B., Alexander  N., al-Yaman  F., Anders  R. F., Alpers  M.
ISSN
0019-9567 (Print)
Statut éditorial
Publié
Date de publication
02/1995
Volume
63
Numéro
2
Pages
596-600
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Feb
Résumé
A parasitological and immunological survey was carried out in an area in Papua New Guinea highly endemic for malaria. Two hundred fourteen adult individuals were selected for studies to assess their immune responses against the malaria vaccine candidate ring-infected erythrocyte surface antigen (RESA). Total immunoglobulin G (IgG) antibodies directed against RESA as well as specific IgG1, IgG2, and IgG3 antibodies were determined. Humoral responses directed against RESA were frequent in all IgG subclasses. Only IgG3 responses were found to be age dependent. Total anti-RESA IgG antibodies were not correlated with protection against malaria as measured by parasite prevalence, parasite density, or health center attendance. In contrast, cytophilic antibodies (IgG1 and IgG3) were associated with reduced Plasmodium falciparum prevalence and reduced health center attendance. T-cell proliferation in general was low and very infrequent. No correlation between humoral and cellular immune responses could be found. Parasite density, parasite prevalence, and health center visits tended to be reduced in individuals with good humoral and cell-mediated immune responses.
Mots-clé
Animals Antibodies, Protozoan/*immunology Antigens, Protozoan/*immunology Antigens, Surface/*immunology Cross-Sectional Studies Humans Immunity, Cellular Immunoglobulin G/immunology Immunoglobulin Isotypes/immunology Lymphocyte Activation Malaria, Falciparum/*immunology New Guinea Plasmodium falciparum/*immunology Protozoan Proteins/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 11:49
Dernière modification de la notice
20/08/2019 14:12
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