Similarity of cutaneous reactive hyperemia in the forearm of women with and without hyperinsulinemia

Détails

ID Serval
serval:BIB_58EBAFB249A4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Similarity of cutaneous reactive hyperemia in the forearm of women with and without hyperinsulinemia
Périodique
International Journal of Obesity and Related Metabolic Disorders
Auteur(s)
Seywert  A. J., Kubli  S., Giusti  V., Feihl  F., Waeber  B., Tappy  L.
ISSN
0307-0565 (Print)
Statut éditorial
Publié
Date de publication
04/2004
Volume
28
Numéro
4
Pages
611-5
Notes
Journal Article --- Old month value: Apr
Résumé
OBJECTIVE: The present study was undertaken to assess in pre- and postmenopausal women whether obesity influences cutaneous reactive hyperemia in the forearm. DESIGN: Cross-sectional study. SUBJECTS AND METHODS: Eight lean premenopausal (age 24.6+/-3.5 y, BMI=21.9+/-1.5 kg/m(2), mean+/-1 s.d.), eight obese premenopausal (age 27.8+/-5.1 y, BMI=35.3+/-5.8 kg/m(2)), eight lean postmenopausal (age 56.1+/-8.3 y, BMI=20.2+/-2.2 kg/m(2)) and eight obese postmenopausal women (age 57.4+/-6.1 y, BMI=32.8+/-3 kg/m(2)) were included. Plasma glucose, insulin and lipid profile were determined in fasting state, and a glucose tolerance test was performed. The skin blood flow response to transient occlusion of the forearm circulation (reactive hyperemia, RH) was measured using a laser-Doppler imaging system. RESULTS: Obese women had hyperinsulinemia, suggesting that they were insulin-resistant. The magnitude of the RH was similar in postmenopausal compared to premenopausal women. Obesity did not influence this microvascular response. CONCLUSION: Obesity, which is known to be associated with impaired endothelial-dependent vasodilation in the skeletal musculature, has no effect on the RH of the forearm skin microcirculation.
Mots-clé
Adult Anthropometry Cross-Sectional Studies Endothelium, Vascular/physiopathology Female Forearm/blood supply Humans Hyperemia/*complications/physiopathology Hyperinsulinism/*complications/physiopathology Laser-Doppler Flowmetry Microcirculation Middle Aged Obesity/*complications/physiopathology Postmenopause/physiology Premenopause/physiology Skin/*blood supply
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
20/08/2019 15:12
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