Penetrating or Stricturing Diseases are the Major Determinants of Time to First and Repeat Resection Surgery in Crohn's Disease.

Détails

ID Serval
serval:BIB_58E2C781D1C9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Penetrating or Stricturing Diseases are the Major Determinants of Time to First and Repeat Resection Surgery in Crohn's Disease.
Périodique
Digestion
Auteur(s)
Pittet V., Rogler G., Michetti P., Fournier N., Vader J.P., Schoepfer A., Mottet C., Burnand B., Froehlich F.
ISSN
1421-9867 (Electronic)
ISSN-L
0012-2823
Statut éditorial
Publié
Date de publication
2013
Volume
87
Numéro
3
Pages
212-221
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Background: About 80% of patients with Crohn's disease (CD) require bowel resection and up to 65% will undergo a second resection within 10 years. This study reports clinical risk factors for resection surgery (RS) and repeat RS. Methods: Retrospective cohort study, using data from patients included in the Swiss Inflammatory Bowel Disease Cohort. Cox regression analyses were performed to estimate rates of initial and repeated RS. Results: Out of 1,138 CD cohort patients, 417 (36.6%) had already undergone RS at the time of inclusion. Kaplan-Meier curves showed that the probability of being free of RS was 65% after 10 years, 42% after 20 years, and 23% after 40 years. Perianal involvement (PA) did not modify this probability to a significant extent. The main adjusted risk factors for RS were smoking at diagnosis (hazard ratio (HR) = 1.33; p = 0.006), stricturing with vs. without PA (HR = 4.91 vs. 4.11; p < 0.001) or penetrating disease with vs. without PA (HR = 3.53 vs. 4.58; p < 0.001). The risk factor for repeat RS was penetrating disease with vs. without PA (HR = 3.17 vs. 2.24; p < 0.05). Conclusion: The risk of RS was confirmed to be very high for CD in our cohort. Smoking status at diagnosis, but mostly penetrating and stricturing diseases increase the risk of RS.
Pubmed
Web of science
Création de la notice
18/07/2013 17:51
Dernière modification de la notice
07/10/2019 15:01
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