Simultaneous active and passive immunization against hepatitis A studied in a population of travellers.

Détails

ID Serval
serval:BIB_585D0BF2C884
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Simultaneous active and passive immunization against hepatitis A studied in a population of travellers.
Périodique
Vaccine
Auteur⸱e⸱s
Wagner G., Lavanchy D., Darioli R., Pécoud A., Brulein V., Safary A., Frei P.C.
ISSN
0264-410X
Statut éditorial
Publié
Date de publication
1993
Peer-reviewed
Oui
Volume
11
Numéro
10
Pages
1027-1032
Langue
anglais
Résumé
Three hundred travellers, seronegative for hepatitis A, were enrolled into this study to evaluate a new inactivated hepatitis A vaccine. Three injections, each containing at least 720 ELISA units, were administered intramuscularly at months 0, 1 and 6. The subjects were distributed into three groups: 100 received vaccine only; 100 received a single injection of immunoglobulin enriched in HAV antibody; and the 100 remaining travellers received the vaccine and immunoglobulin administered simultaneously with the first vaccine dose. In both vaccinated groups, the rate of seroconversion was found to be higher than 90% at month 1, reaching 100% and 97.8% at month 2 in groups 1 and 3, respectively, and 100% at month 7. In the group receiving both vaccine and immunoglobulin, antibody production was somewhat slower and the final titres were, on average, slightly lower than those obtained in the group with the vaccine alone (GMT 2488 and 3614 mIU ml-1 respectively; p = 0.02). The vaccine appeared to be highly immunogenic in all subjects and was also well tolerated. The slight inhibition of antibody production, induced by the concurrent administration of immunoglobulin, does not affect the overall protection afforded by the vaccine. We conclude that simultaneous active and passive hepatitis A immunizations can be recommended.
Mots-clé
Adolescent, Adult, Alanine Transaminase, Female, Hepatitis A, Hepatitis A Antibodies, Hepatitis A Vaccines, Hepatitis Antibodies, Hepatovirus, Humans, Immunization, Passive, Male, Middle Aged, Vaccination, Vaccines, Inactivated, Viral Hepatitis Vaccines
Pubmed
Web of science
Création de la notice
28/01/2008 11:59
Dernière modification de la notice
20/08/2019 14:12
Données d'usage