Congenital diaphragmatic hernia : a European population-based study of epidemiology, prenatal diagnosis and mortality

Détails

ID Serval
serval:BIB_581BF62044E1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Congenital diaphragmatic hernia : a European population-based study of epidemiology, prenatal diagnosis and mortality
Périodique
Prenatal and Neonatal Medicine
Auteur(s)
Garne E., Quataert P., de Vigan C., Mendizabal H., Igoe D., Addor M.C., Moro-Bayon C., Garcia-Minaur S.
ISSN
1359-8635
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
4
Numéro
6
Pages
441-447
Langue
anglais
Résumé
Aim: To study the epidemiology and the impact of prenatal diagnosis on mortality and morbidity in infants with isolated congenital diaphragmatic hernia (CDH).
Methods: Cases were identified in eight population-based registries of congenital malformations (Eurocat) in Europe.
Results: A total of 183 live births were included in the study. Sixty per cent died and 67% of all deaths were during the first day of life. CDH was diagnosed prenatally in 39% of cases. Both mortality and morbidity were significantly higher for infants diagnosed prenatally compared to those diagnosed postnatally. The Apgar score was a very sensitive indicator for survival. Gestational age at birth was significantly lower for infants diagnosed prenatally compared to those diagnosed postnatally (37.6 weeks vs. 38.8 weeks, p < 0.01). At the end of follow-up, half of the survivors were leading a normal life. The most frequently reported health problems were respiratory and gastrointestinal symptoms.
Conclusions: In this population-based study, mortality for infants with CDH was high (60%) and early prenatal diagnosis was a risk factor for survival. Intervention at the time of birth seems too late for the majority of newborn infants with CDH.
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Création de la notice
02/04/2009 10:43
Dernière modification de la notice
20/08/2019 14:11
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