Antibiotics as Instigators of Microbial Dysbiosis: Implications for Asthma and Allergy.

Détails

ID Serval
serval:BIB_58197445129A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Antibiotics as Instigators of Microbial Dysbiosis: Implications for Asthma and Allergy.
Périodique
Trends in immunology
Auteur(s)
Wypych T.P., Marsland B.J.
ISSN
1471-4981 (Electronic)
ISSN-L
1471-4906
Statut éditorial
Publié
Date de publication
09/2018
Peer-reviewed
Oui
Volume
39
Numéro
9
Pages
697-711
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The human body and its resident microbiota form a complex ecosystem, shaped by both inherited and environmental factors. The use of antibiotics represents an extreme example of environmental pressure and can broadly disrupt the microbial landscape. The benefits that antibiotics have brought to modern medicine are unquestionable; however, their overuse comes with consequences, including the potential for secondary infections by opportunistic pathogens and the spread of antibiotic resistance. Here, we discuss the implications of microbial dysbiosis driven by antibiotics, with a focus on potential links with allergy and asthma. We review epidemiological data on humans, as well as mechanistic studies performed in animal models, and highlight gaps in current knowledge, which if addressed, could drive the design of novel therapeutic strategies and improved clinical care.
Mots-clé
Animals, Anti-Bacterial Agents/adverse effects, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Asthma/epidemiology, Asthma/etiology, Disease Models, Animal, Drug Resistance, Bacterial, Dysbiosis/drug therapy, Dysbiosis/microbiology, Humans, Hypersensitivity/epidemiology, Hypersensitivity/etiology, Immune System/cytology, Immune System/immunology, Immune System/metabolism, Microbiota/drug effects, allergy, antibiotics, microbiota
Pubmed
Web of science
Création de la notice
19/04/2018 18:54
Dernière modification de la notice
20/08/2019 15:11
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