Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics.

Détails

Ressource 1Télécharger: fnins-12-00485.pdf (534.43 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_57E623106707
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics.
Périodique
Frontiers in Neuroscience
Auteur⸱e⸱s
Nuno-Perez A., Tchenio A., Mameli M., Lecca S.
ISSN
1662-4548 (Print)
ISSN-L
1662-453X
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
12
Pages
485
Langue
anglais
Résumé
Depression is a highly heterogeneous disease characterized by symptoms spanning from anhedonia and behavioral despair to social withdrawal and learning deficit. Such diversity of behavioral phenotypes suggests that discrete neural circuits may underlie precise aspects of the disease, rendering its treatment an unmet challenge for modern neuroscience. Evidence from humans and animal models indicate that the lateral habenula (LHb), an epithalamic center devoted to processing aversive stimuli, is aberrantly affected during depression. This raises the hypothesis that rescuing maladaptations within this nucleus may be a potential way to, at least partially, treat aspects of mood disorders. In this review article, we will discuss pre-clinical and clinical evidence highlighting the role of LHb and its cellular adaptations in depression. We will then describe interventional approaches aiming to rescue LHb dysfunction and ultimately ameliorate depressive symptoms. Altogether, we aim to merge the mechanistic-, circuit-, and behavioral-level knowledge obtained about LHb maladaptations in depression to build a general framework that might prove valuable for potential therapeutic interventions.
Mots-clé
antidepressants, cellular mechanisms, deep brain stimulation, depression, lateral habenula (LHb)
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/08/2018 12:44
Dernière modification de la notice
20/08/2019 15:11
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