Effects of intravenously infused fish oil on platelet fatty acid phospholipid composition and on platelet function in postoperative trauma

Détails

ID Serval
serval:BIB_57E2750A424B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of intravenously infused fish oil on platelet fatty acid phospholipid composition and on platelet function in postoperative trauma
Périodique
JPEN: Journal of Parenteral and Enteral Nutrition
Auteur⸱e⸱s
Roulet  M., Frascarolo  P., Pilet  M., Chapuis  G.
ISSN
0148-6071 (Print)
Statut éditorial
Publié
Date de publication
10/1997
Volume
21
Numéro
5
Pages
296-301
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Sep-Oct
Résumé
BACKGROUND: The aim of this study was to assess the short-term effect of IV infusion of fish oil emulsion on the fatty acid profiles of platelet phosphatidylcholine and phosphatidylethanolamine and on platelet function in postoperative patients. METHODS: Over a 7-day period, 10 patients received a 20% soybean fat emulsion with an added 10% marine fish oil emulsion, whereas 9 controls received only 20% soybean fat emulsion. RESULTS: By comparison with controls, in patients receiving fish oil, (1) a large increase in eicosapentaenoic acid (20:5n-3) was observed in both platelet phosphatidylcholine (1.55% +/- 0.17% vs 0.38% +/- 0.06% by weight, p < .01) and phosphatidylethanolamine 2.21% +/- 0.18% vs 0.66% +/- 0.08% by weight, p < .01); (2) eicosapentaenoic acid (20:5n-3)/arachidonic acid (20:4n-6) ratios doubled in both platelet phosphatidylcholine (p < .01) and phosphatidylethanolamine (p < .05); (3) with collagen as aggregating factor, maximal reaction speed decreased (p < .02) and latency increased (p < .002); and (4) no toxic effect, in particular no increase of postoperative bleeding and no perturbation of hepatic and renal function, was observed during the fish oil infusion. CONCLUSIONS: A short-term IV infusion of fish oil clearly modifies the platelet composition and changes some parameters of platelet function.
Mots-clé
Blood Platelets/*chemistry/*physiology Cohort Studies Fat Emulsions, Intravenous/*administration & dosage Fish Oils/*administration & dosage Humans Infusions, Intravenous Middle Aged Parenteral Nutrition/*methods Phosphatidylcholines/analysis/chemistry/classification Phosphatidylethanolamines/analysis/chemistry/classification Phospholipids/*analysis/chemistry/classification Postoperative Period Time Factors United States
Pubmed
Web of science
Création de la notice
24/01/2008 20:33
Dernière modification de la notice
20/08/2019 14:11
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