Does the contribution of human milk oligosaccharides to the beneficial effects of breast milk allow us to hope for an improvement in infant formulas?

Détails

ID Serval
serval:BIB_57A844694023
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Does the contribution of human milk oligosaccharides to the beneficial effects of breast milk allow us to hope for an improvement in infant formulas?
Périodique
Critical reviews in food science and nutrition
Auteur⸱e⸱s
Chouraqui J.P.
ISSN
1549-7852 (Electronic)
ISSN-L
1040-8398
Statut éditorial
Publié
Date de publication
2021
Peer-reviewed
Oui
Volume
61
Numéro
9
Pages
1503-1514
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Human milk is a source of nutrients and contains many distinct bioactive components. Among these, human milk oligosaccharides (HMOs) have attracted considerable attention and are being investigated as a "novel foods". Human milk is unique in its oligosaccharide composition. Recent research has focused on the complexity of HMOs by highlighting their diversity, structural variability, concentration variance, and structure-function relationships. In vitro and in vivo studies have demonstrated that HMOs drive infant gut microbiota, improve intestinal barrier functions, and modulate cell receptor signaling, thereby contributing to the development of infant immunity. These studies, combined with epidemiological data, indicate that some HMO may confer health benefits by preventing infections and diseases such as necrotizing enterocolitis and allergies. However, randomized controlled trials are restricted to structurally simple compounds such as 2' fucosyllactose and lacto-N-neotetraose. More controlled clinical trials are needed to justify routine supplementation of formula. It is felt that a better understanding of the role of HMOs leading to the development of inexpensive methods for large-scale HMO production is needed.
Mots-clé
Animals, Female, Gastrointestinal Microbiome, Humans, Infant, Infant Formula/analysis, Infant, Newborn, Milk, Human, Oligosaccharides, Functional food, microbiota, prebiotic, prevention of infant diseases
Pubmed
Web of science
Création de la notice
15/06/2020 15:31
Dernière modification de la notice
02/12/2023 8:15
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