Explaining additional genetic variation in complex traits.

Détails

ID Serval
serval:BIB_57A21E9B0CA1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Explaining additional genetic variation in complex traits.
Périodique
Trends in Genetics
Auteur(s)
Robinson M.R., Wray N.R., Visscher P.M.
ISSN
0168-9525 (Print)
ISSN-L
0168-9525
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
30
Numéro
4
Pages
124-132
Langue
anglais
Résumé
Genome-wide association studies (GWAS) have provided valuable insights into the genetic basis of complex traits, discovering >6000 variants associated with >500 quantitative traits and common complex diseases in humans. The associations identified so far represent only a fraction of those that influence phenotype, because there are likely to be many variants across the entire frequency spectrum, each of which influences multiple traits, with only a small average contribution to the phenotypic variance. This presents a considerable challenge to further dissection of the remaining unexplained genetic variance within populations, which limits our ability to predict disease risk, identify new drug targets, improve and maintain food sources, and understand natural diversity. This challenge will be met within the current framework through larger sample size, better phenotyping, including recording of nongenetic risk factors, focused study designs, and an integration of multiple sources of phenotypic and genetic information. The current evidence supports the application of quantitative genetic approaches, and we argue that one should retain simpler theories until simplicity can be traded for greater explanatory power.

Mots-clé
Animals, Genetic Variation, Genome/genetics, Humans, Phenotype, Quantitative Trait, Heritable
Pubmed
Web of science
Création de la notice
06/12/2017 13:42
Dernière modification de la notice
20/08/2019 15:11
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