Does tolterodine extended release affect the bladder electrical perception threshold? A placebo controlled, double-blind study with 4 and 8 mg in healthy volunteers.

Détails

ID Serval
serval:BIB_57940B49A4DF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Does tolterodine extended release affect the bladder electrical perception threshold? A placebo controlled, double-blind study with 4 and 8 mg in healthy volunteers.
Périodique
Journal of Urology
Auteur(s)
Mehnert U., Reitz A., Ziegler M., Knapp P.A., Schurch B.
ISSN
1527-3792 (Electronic)
ISSN-L
0022-5347
Statut éditorial
Publié
Date de publication
2007
Volume
178
Numéro
6
Pages
2495-2500
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled TrialPublication Status: ppublish
Résumé
PURPOSE: We evaluated the influence of tolterodine extended release on human bladder afferents. The afferents were assessed by determining the bladder electrical perception threshold using endovesical electrical stimulation at different potentially neuroselective frequencies.
MATERIALS AND METHODS: A total of 30 healthy female subjects with a mean +/- SD age of 23.6 +/- 2.3 years and a mean body mass index of 20.5 +/- 1.7 kg/m2 were assigned to 3 groups of 10 each in a double-blind manner, including group 1-placebo, group 2-4 mg tolterodine extended release and group 3-8 mg tolterodine extended release. The investigation was performed using an 8Fr catheter for filling and stimulation that was placed at the bladder neck in a 100 ml filled bladder. Bipolar stimulation was performed using 2.5, 5 and 250 Hz stimuli. Subjects were asked to indicate sensation by pressing a button. Electrical perception thresholds were determined using the method of levels. Electrical perception thresholds were determined before and 4 hours after medication.
RESULTS: No significant change in the electrical perception threshold after treatment could be found among the groups at 2.5, 5 and 250 Hz (p = 0.178, 0.817 and 0.365, respectively). There was a tendency in the tolterodine extended release groups toward an increased electrical perception threshold at 250 Hz (4 mg less than 8 mg). In most cases electrical stimulation with 2.5 and 5 Hz was described as a slight twinge, tickle or desire to void. Stimulation with 250 Hz was the most uncomfortable one, described as a strong, distinct twinge or burning "like urinary tract infection."
CONCLUSIONS: Although a tendency was observed toward an increased electrical perception threshold at 250 Hz, this study showed no significant effect of tolterodine extended release on the bladder electrical perception threshold.
Mots-clé
Administration, Oral, Adult, Benzhydryl Compounds/administration & dosage, Cresols/administration & dosage, Delayed-Action Preparations/administration & dosage, Dose-Response Relationship, Drug, Double-Blind Method, Electric Stimulation/methods, Female, Humans, Muscarinic Antagonists/administration & dosage, Phenylpropanolamine/administration & dosage, Reference Values, Sensitivity and Specificity, Sensory Thresholds/drug effects, Urinary Bladder/drug effects, Urinary Bladder/innervation, Urinary Catheterization, Urodynamics/physiology
Pubmed
Web of science
Création de la notice
05/11/2014 13:12
Dernière modification de la notice
20/08/2019 15:11
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