New gene functions in megakaryopoiesis and platelet formation.

Détails

Ressource 1Télécharger: 22139419_Postprint.pdf (1207.82 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_5793840A79A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
New gene functions in megakaryopoiesis and platelet formation.
Périodique
Nature
Auteur⸱e⸱s
Gieger C., Radhakrishnan A., Cvejic A., Tang W., Porcu E., Pistis G., Serbanovic-Canic J., Elling U., Goodall A.H., Labrune Y., Lopez L.M., Mägi R., Meacham S., Okada Y., Pirastu N., Sorice R., Teumer A., Voss K., Zhang W., Ramirez-Solis R., Bis J.C., Ellinghaus D., Gögele M., Hottenga J.J., Langenberg C., Kovacs P., O'Reilly P.F., Shin S.Y., Esko T., Hartiala J., Kanoni S., Murgia F., Parsa A., Stephens J., van der Harst P., Ellen van der Schoot C., Allayee H., Attwood A., Balkau B., Bastardot F., Basu S., Baumeister S.E., Biino G., Bomba L., Bonnefond A., Cambien F., Chambers J.C., Cucca F., D'Adamo P., Davies G., de Boer R.A., de Geus E.J., Döring A., Elliott P., Erdmann J., Evans D.M., Falchi M., Feng W., Folsom A.R., Frazer I.H., Gibson Q.D., Glazer N.L., Hammond C., Hartikainen A.L., Heckbert S.R., Hengstenberg C., Hersch M., Illig T., Loos R.J., Jolley J., Tee Khaw K., Kühnel B., Kyrtsonis M.C., Lagou V., Lloyd-Jones H., Lumley T., Mangino M., Maschio A., Mateo Leach I., McKnight B., Memari Y., Mitchell B.D., Montgomery G.W., Nakamura Y., Nauck M., Navis G., Nöthlings U., Nolte I.M., Porteous D.J., Pouta A., Pramstaller P.P., Pullat J., Ring S.M., Rotter J.I., Ruggiero D., Ruokonen A., Sala C., Samani N.J., Sambrook J., Schlessinger D., Schreiber S., Schunkert H., Scott J., Smith N.L., Snieder H., Starr J.M., Stumvoll M., Takahashi A., Tang W.H., Taylor K., Tenesa A., Lay Thein S., Tönjes A., Uda M., Ulivi S., van Veldhuisen D.J., Visscher P.M., Völker U., Wichmann H.E., Wiggins K.L., Willemsen G., Yang T.P., Hua Zhao J., Zitting P., Bradley J.R., Dedoussis G.V., Gasparini P., Hazen S.L., Metspalu A., Pirastu M., Shuldiner A.R., Joost van Pelt L., Zwaginga J.J., Boomsma D.I., Deary I.J., Franke A., Froguel P., Ganesh S.K., Jarvelin M.R., Martin N.G., Meisinger C., Psaty B.M., Spector T.D., Wareham N.J., Akkerman J.W., Ciullo M., Deloukas P., Greinacher A., Jupe S., Kamatani N., Khadake J., Kooner J.S., Penninger J., Prokopenko I., Stemple D., Toniolo D., Wernisch L., Sanna S., Hicks A.A., Rendon A., Ferreira M.A., Ouwehand W.H., Soranzo N.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
2011
Volume
480
Numéro
7376
Pages
201-208
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Résumé
Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding of the molecular processes controlling both traits. Here we carried out a high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry, followed by extensive biological and functional assessment. We identified 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation. These genes show megakaryocyte-specific gene expression patterns and extensive network connectivity. Using gene silencing in Danio rerio and Drosophila melanogaster, we identified 11 of the genes as novel regulators of blood cell formation. Taken together, our findings advance understanding of novel gene functions controlling fate-determining events during megakaryopoiesis and platelet formation, providing a new example of successful translation of GWAS to function.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/12/2011 10:32
Dernière modification de la notice
18/01/2021 21:50
Données d'usage