Epidemiologie und Risikofaktoren der gastroduodenalen Ulcuskrankheit [Epidemiology and risk factors of gastroduodenal ulcer]

Détails

ID Serval
serval:BIB_5792
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Epidemiologie und Risikofaktoren der gastroduodenalen Ulcuskrankheit [Epidemiology and risk factors of gastroduodenal ulcer]
Périodique
Der Chirurg
Auteur(s)
Kreiss C., Blum A.L.
ISSN
0009-4722
Statut éditorial
Publié
Date de publication
1996
Volume
67
Numéro
1
Pages
7-13
Langue
allemand
Notes
Publication types: English Abstract ; Journal Article ; Review
Résumé
Today, the lifetime prevalence of peptic ulcer disease is in industrialized countries approximately 5 to 10%. There has been a substantial decline in peptic ulcer incidence and mortality over the last forty years. The two principal, independent risk factors of gastric and duodenal ulcer disease are a preexisting Helicobacter pylori infection and the regular intake of nonsteroidal anti-inflammatory drugs (NSAID). Several characteristics of H. pylori infection which contribute to the final event of ulceration have been identified. Bacterial virulence factors and the severity of gastritis seem to play an important role. It remains unclear, whether the degree of gastritis is due to host factors or to the pathogen. NSAID-induced peptic ulcers are often asymptomatic and therefore diagnosis is not being made until complications arise. NSAID-ulcers often bleed. NSAID ulceration can induced develop already after a short course of treatment. The combination of NSAIDs with anticoagulants or corticosteroids potentiates the ulcer risk. Age, diet, smoking and psychological factors have a rather permissive and optional influence on peptic ulcer pathogenesis.
Mots-clé
Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Cross-Sectional Studies, Helicobacter Infections/complications, Helicobacter Infections/epidemiology, Helicobacter pylori, Humans, Incidence, Peptic Ulcer/epidemiology, Peptic Ulcer/etiology, Peptic Ulcer Hemorrhage/epidemiology, Peptic Ulcer Hemorrhage/etiology, Risk Factors, Switzerland/epidemiology
Pubmed
Web of science
Création de la notice
19/11/2007 12:42
Dernière modification de la notice
20/08/2019 14:11
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