Mixed medullary-papillary carcinoma of the thyroid: report of a case and review of the literature.

Détails

ID Serval
serval:BIB_573CF11E37E5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Mixed medullary-papillary carcinoma of the thyroid: report of a case and review of the literature.
Périodique
Head & Neck
Auteur(s)
Nangue C., Bron L., Portmann L., Volante M., Ris H.B., Monnier P., Andrejevic-Blant S.
ISSN
1097-0347[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
31
Numéro
7
Pages
968-74
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Review
Résumé
BACKGROUND: Mixed medullary-follicular thyroid carcinoma denotes a rare and heterogeneous group of tumors displaying morphological and immunophenotypical features of both origins within the same lesion. METHOD: We report a case of a 41-year-old woman with a lump in the right side of the neck, increasing in pain and size over several weeks. Serum levels of calcitonine (1140 ng/L) and carcinoembryonic antigen (288 microg/L) were very high. Fine-needle aspiration cytology suggested a diagnosis of medullary thyroid carcinoma. Total thyroidectomy, along with bilateral functional neck and mediastinal lymph-node dissection, were performed. RESULTS: The histopathological examination yielded a diagnosis of medullary carcinoma in the right thyroid lobe, closely intermingled with a nonencapsulated classical papillary carcinoma. One ipsilateral lymph node showed micrometastasis of the medullary counterpart. CONCLUSION: When compared with other cases reported in literature, this particular presentation should be recognized, if required, morphologic and functional criteria are used. The treatment is mostly surgical, driven by the medullary component. The presence of micrometastasis in 1 ipsilateral cervical lymph-node underlines the importance of cervicomediastinal lymph-node dissection and careful searching for metastatic disease.
Mots-clé
Adult, Carcinoma, Medullary/pathology, Carcinoma, Medullary/surgery, Carcinoma, Papillary/pathology, Carcinoma, Papillary/surgery, Female, Humans, Mixed Tumor, Malignant/pathology, Mixed Tumor, Malignant/surgery, Thyroid Neoplasms/pathology, Thyroid Neoplasms/surgery, Thyroidectomy
Pubmed
Web of science
Création de la notice
30/10/2009 17:23
Dernière modification de la notice
20/08/2019 15:11
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