Protective Efficacy of Individual CD8+ T Cell Specificities in Chronic Viral Infection.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_573CA9490658
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Protective Efficacy of Individual CD8+ T Cell Specificities in Chronic Viral Infection.
Périodique
Journal of Immunology
Auteur(s)
Johnson S., Bergthaler A., Graw F., Flatz L., Bonilla W.V., Siegrist C.A., Lambert P.H., Regoes R.R., Pinschewer D.D.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
194
Numéro
4
Pages
1755-1762
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Specific CD8(+) T cells (CTLs) play an important role in resolving protracted infection with hepatitis B and C virus in humans and lymphocytic choriomeningitis virus (LCMV) in mice. The contribution of individual CTL specificities to chronic virus control, as well as epitope-specific patterns in timing and persistence of antiviral selection pressure, remain, however, incompletely defined. To monitor and characterize the antiviral efficacy of individual CTL specificities throughout the course of chronic infection, we coinoculated mice with a mixture of wild-type LCMV and genetically engineered CTL epitope-deficient mutant virus. A quantitative longitudinal assessment of viral competition revealed that mice continuously exerted CTL selection pressure on the persisting virus population. The timing of selection pressure characterized individual epitope specificities, and its magnitude varied considerably between individual mice. This longitudinal assessment of "antiviral efficacy" provides a novel parameter to characterize CTL responses in chronic viral infection. It demonstrates remarkable perseverance of all antiviral CTL specificities studied, thus raising hope for therapeutic vaccination in the treatment of persistent viral diseases.
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/03/2015 19:34
Dernière modification de la notice
20/08/2019 15:11
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