Incidental uptake of 18F-fluorodeoxyglucose in the prostate gland. Systematic review and meta-analysis on prevalence and risk of malignancy.

Détails

ID Serval
serval:BIB_5735EDBF956F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Incidental uptake of 18F-fluorodeoxyglucose in the prostate gland. Systematic review and meta-analysis on prevalence and risk of malignancy.
Périodique
Nuklearmedizin. Nuclear medicine
Auteur(s)
Bertagna F., Sadeghi R., Giovanella L., Treglia G.
ISSN
0029-5566 (Print)
ISSN-L
0029-5566
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
53
Numéro
6
Pages
249-258
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Résumé
To perform a systematic review and meta-analysis of published data on the prevalence and risk of malignancy of prostatic incidental uptake (PIU) detected by fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT).
A comprehensive literature search of studies published up to February 2014 was performed. Pooled prevalence and malignancy risk of PIU were calculated on a per patient-based analysis including 95% confidence interval (95%CI). Furthermore, we assessed some parameters as potential predictors of malignant PIU.
Six studies including 47925 patients who underwent 18F-FDG PET/CT were selected. Pooled prevalence of PIU was 1.8% (95%CI: 1.3-2.3%). Overall, 444 patients with PIU were further evaluated and 121 underwent biopsy. The pooled risk of malignancy in patients with PIU further evaluated or verified by biopsy were 17% (95%CI: 12-23%) and 62% (95%CI: 54-71%), respectively. A higher mean age was observed in the group of malignant PIUs compared to benign PIUs. There was a trend towards a higher mean SUV(max) in the group of malignant PIUs but without a statistically significant difference compared to benign PIUs. Peripheric site of PIU but not presence or absence of calcification was a predictor of malignancy.
PIU is observed in about 1.8% of 18F-FDG PET/CT scans performed in male patients carrying a significant risk of malignancy. Therefore, whenever a PIU is detected further investigation is warranted to exclude malignancy, in particular when PIU is located in the peripheric site of prostate gland.

Mots-clé
Fluorodeoxyglucose F18/pharmacokinetics, Humans, Incidence, Incidental Findings, Male, Prostatic Neoplasms/diagnosis, Prostatic Neoplasms/metabolism, Radiopharmaceuticals/pharmacokinetics, Reproducibility of Results, Risk Factors, Sensitivity and Specificity, PET/CT, Prostate, incidental uptake, meta-analysis
Pubmed
Web of science
Création de la notice
20/08/2017 17:27
Dernière modification de la notice
20/08/2019 14:11
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