Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells
Détails
ID Serval
serval:BIB_56BF10EBEFC8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells
Périodique
Infection and Immunity
ISSN
0019-9567 (Print)
Statut éditorial
Publié
Date de publication
06/1998
Volume
66
Numéro
6
Pages
3003-5
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jun
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jun
Résumé
The endothelial cell interactions of homozygous null mutants of Candida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicans adherence to endothelial cells.
Mots-clé
Aspartic Endopeptidases/*secretion
Candida albicans/enzymology/*pathogenicity
Cell Adhesion
E-Selectin/biosynthesis
Endothelium, Vascular/*microbiology/pathology
Fungal Proteins/*secretion
Humans
Pubmed
Web of science
Création de la notice
25/01/2008 15:40
Dernière modification de la notice
20/08/2019 15:10
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