A single administration of tetanus toxoid in biodegradable microspheres elicits T cell and antibody responses similar or superior to those obtained with aluminum hydroxide

Détails

ID Serval
serval:BIB_568CACF30B5C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A single administration of tetanus toxoid in biodegradable microspheres elicits T cell and antibody responses similar or superior to those obtained with aluminum hydroxide
Périodique
Vaccine
Auteur(s)
Men  Y., Thomasin  C., Merkle  H. P., Gander  B., Corradin  G.
ISSN
0264-410X (Print)
Statut éditorial
Publié
Date de publication
05/1995
Volume
13
Numéro
7
Pages
683-9
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
The use of biodegradable polymer microspheres as a single dose vaccine delivery system was investigated by using tetanus toxoid (TT). In order to compare the immunogenicity of TT-microspheres (TT-MS) with aluminum hydroxide (alum)-based TT, BALB/c mice were immunized with TT in different formulations including individual or mixtures of MS and TT-alum. All TT-MS formulations elicited high proliferative and antibody responses comparable to those obtained with TT-alum formulation. Antibody levels remained elevated over a long period of time. Certain individual MS preparations elicited lower antibody titers than the MS mixtures. More importantly, the proliferative and antibody responses induced by a single injection of three TT-MS mixtures with different particle sizes and degradation rates were similar to those obtained with three injections of TT-alum. In addition, TT-MS induce similar isotypesubclass antibodies to those TT-alum induced. These results raise the possibility to obtain optimal and long-lasting immune responses by single administration of the three TT-MS mixture formulations alone.
Mots-clé
Aluminum Hydroxide/*administration & dosage Animals Antibodies, Bacterial/*biosynthesis Female Immunization Lymphocyte Activation Mice Mice, Inbred BALB C Microspheres T-Lymphocytes/*immunology Tetanus Toxoid/administration & dosage/*immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:55
Dernière modification de la notice
20/08/2019 14:10
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