Comparison of betaxolol with verapamil in hypertensive patients: discrepancy between office and ambulatory blood pressures.

Détails

ID Serval
serval:BIB_5645A0CDCABE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Comparison of betaxolol with verapamil in hypertensive patients: discrepancy between office and ambulatory blood pressures.
Périodique
Journal of hypertension
Auteur(s)
Waeber G., Beck G., Waeber B., Bidiville J., Nussberger J., Brunner H.R.
ISSN
0263-6352
Statut éditorial
Publié
Date de publication
1988
Peer-reviewed
Oui
Volume
6
Numéro
3
Pages
239-45
Langue
anglais
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
The purpose of this study was to compare in the individual hypertensive patient the blood pressure lowering effect of a beta-blocking agent i.e. betaxolol with that of a calcium entry blocker, i.e. verapamil. The antihypertensive efficacy of the drugs was evaluated both at the physician's office and by monitoring ambulatory daytime blood pressure using a portable blood pressure recorder (Remler M2000). Seventeen patients with uncomplicated essential hypertension (aged 35-67 years) were treated for two consecutive 6-week periods with either betaxolol, 20 mg/day or a slow-release formulation of verapamil, 240-480 mg/day. The sequence of treatment phases was randomly allocated and a 2-week wash-out period preceded each treatment. Both betaxolol and verapamil had a significant blood pressure lowering effect when assessed at the physician's office. However, ambulatory recorded blood pressures were significantly reduced only with betaxolol. In the presence of a physician, the best responders to betaxolol tended to be also the best responders to verapamil, whereas there was no relationship between the fall in ambulatory recorded blood pressure observed during betaxolol and the corresponding fall during verapamil administration. The blood pressure response to both betaxolol and verapamil was not related to age.
Mots-clé
Adult, Aged, Betaxolol, Blood Pressure, Blood Pressure Determination, Clinical Trials as Topic, Female, Humans, Hypertension, Male, Middle Aged, Propanolamines, Random Allocation, Verapamil
Pubmed
Web of science
Création de la notice
25/01/2008 15:10
Dernière modification de la notice
20/08/2019 15:10
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