Differential migration of in vivo primed B and T lymphocytes to lymphoid and non-lymphoid organs.

Détails

ID Serval
serval:BIB_5638C8638347
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Differential migration of in vivo primed B and T lymphocytes to lymphoid and non-lymphoid organs.
Périodique
European Journal of Immunology
Auteur(s)
Finke D., Acha-Orbea H.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
31
Numéro
9
Pages
2603-2611
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Our study describes tissue-specific migration of T and B cells during a localized anti-viral immune response. After mouse mammary tumor virus (MMTV) injection, B lymphocytes of the draining lymph node become infected and present a retroviral superantigen to CD4(+) T lymphocytes. Infected B cells receive superantigen-mediated help in a fashion comparable to classical immune responses. To investigate the fate of T and B lymphocytes that had interacted via cognate help in the same peripheral lymph node microenvironment we adoptively transferred them into naive recipients. Here we show that MMTV-infected B cells and superantigen-stimulated T cells were programmed to migrate to distinct sites of the body. Plasmablasts but not T cells migrated to the mammary gland and activated alpha4beta1 integrins were found to have a crucial role in the migration to the mammary gland. In contrast, T cells had a much higher affinity for secondary lymphoid organs and large intestine. This demonstrates that upon antigen-driven B and T lymphocyte interaction in the local draining lymph node a subset-specific homing program for B and T lymphocytes is induced.
Mots-clé
Adoptive Transfer, Animals, Antigens, Viral/immunology, B-Lymphocytes/immunology, B-Lymphocytes/transplantation, Breast/immunology, CD4-Positive T-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/transplantation, Cell Movement, Female, Integrin alpha4beta1, Integrins/physiology, Lymphocyte Activation, Lymphoid Tissue/immunology, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Receptors, Lymphocyte Homing/physiology, Retroviridae Infections/immunology, Superantigens/immunology, Vascular Cell Adhesion Molecule-1/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
20/08/2019 15:10
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