Magnetic and in vitro heating properties of implants formed in situ from injectable formulations and containing superparamagnetic iron oxide nanoparticles (SPIONs) embedded in silica microparticles for magnetically induced local hyperthermia

Détails

ID Serval
serval:BIB_5625B167A25D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Magnetic and in vitro heating properties of implants formed in situ from injectable formulations and containing superparamagnetic iron oxide nanoparticles (SPIONs) embedded in silica microparticles for magnetically induced local hyperthermia
Périodique
Journal of Magnetism and Magnetic Materials
Auteur⸱e⸱s
Le Renard Pol-E. , Lortz R., Senatore C., Rapin J.P., Buchegger F., Petri-Fink A., Hofmann H., Doelker E., Jordan O.
ISSN
0304-8853
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
323
Numéro
8
Pages
1054-1063
Langue
anglais
Résumé
The biological and therapeutic responses to hyperthermia, when it is envisaged as an anti-tumor treatment modality, are complex and variable. Heat delivery plays a critical role and is counteracted by more or less efficient body cooling, which is largely mediated by blood flow. In the case of magnetically mediated modality, the delivery of the magnetic particles, most often superparamagnetic iron oxide nanoparticles (SPIONs), is also critically involved. We focus here on the magnetic characterization of two injectable formulations able to gel in situ and entrap silica microparticles embedding SPIONs. These formulations have previously shown suitable syringeability and intratumoral distribution in vivo. The first formulation is based on alginate, and the second on a poly(ethylene-co-vinyl alcohol) (EVAL). Here we investigated the magnetic properties and heating capacities in an alternating magnetic field (141 kHz, 12 mT) for implants with increasing concentrations of magnetic microparticles. We found that the magnetic properties of the magnetic microparticles were preserved using the formulation and in the wet implant at 37 degrees C, as in vivo. Using two orthogonal methods, a common SLP (20 Wg(-1)) was found after weighting by magnetic microparticle fraction, suggesting that both formulations are able to properly carry the magnetic microparticles in situ while preserving their magnetic properties and heating capacities. (C) 2010 Elsevier B.V. All rights reserved.
Mots-clé
Magnetically mediated hyperthermia, Superparamagnetism, SPIONS, Microparticles, Composite magnetic microparticles, Injectable formulations, In situ forming implant, Magnetic properties, SQUID, Heating, AMF, Specific power loss, Calorimetry, Pycnometry, Laser diffraction, DFX, TEM, SEM, FERRIMAGNETIC GLASS-CERAMICS, THERMAL THERAPY, SHOCK PROTEINS, CELLS, PARTICLES, NANOCOMPOSITES, IMMUNOTHERAPY, EXPRESSION, STRESS, MATRIX
Web of science
Création de la notice
22/02/2011 15:05
Dernière modification de la notice
20/08/2019 15:10
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