Cognitive features in euthymic bipolar patients in old age.

Détails

ID Serval
serval:BIB_55BAB6083734
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cognitive features in euthymic bipolar patients in old age.
Périodique
Bipolar Disorders
Auteur(s)
Delaloye C., Moy G., Baudois S., de Bilbao F., Remund C.D., Hofer F., Ragno Paquier C., Campos L., Weber K., Gold G., Moussa A., Meiler C.C., Giannakopoulos P.
ISSN
1399-5618[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
11
Numéro
7
Pages
735-743
Langue
anglais
Résumé
OBJECTIVES: Studies of cognition in bipolar disorder (BD) have reported impairments in processing speed, working memory, episodic memory, and executive function, but they have primarily focused on young and middle-aged adults. In such studies, the severity of cognitive deficits increases with the duration of illness. Therefore, one would expect more pronounced deficits in patients with longstanding BD. The first aim of the present study was to determine the pattern and the magnitude of cognitive impairment in older euthymic BD patients. The second aim was to explore the interrelationship between these cognitive deficits and determine whether they reflect a single core impairment or the co-occurrence of independent cognitive deficits. METHODS: Twenty-two euthymic elderly BD patients and 22 controls, matched for gender, age, and education, underwent a comprehensive neuropsychological assessment. RESULTS: Compared to controls, BD patients had significantly reduced performance in processing speed, working memory, verbal fluency, and episodic memory, but not in executive function. Hierarchical regression analyses showed that verbal fluency and working memory impairments were fully mediated by changes in processing speed. This was not the case for the episodic memory dysfunction. CONCLUSION: The cognitive profile in older euthymic BD cases is similar to the one described in younger BD cohorts. Our results further suggest that impaired processing speed plays a major role in the cognitive changes observed in BD patients except for deficits in episodic memory, thus providing strong evidence that processing speed and episodic memory are two core deficits in elderly BD patients.
Mots-clé
Bipolar Disorder, Episodic Memory, Neuropsychology, Older Adults, Processing Speed, Processing-Speed, Alzheimers-Disease, Executive Function, Affective-Disorder, Memory Impairment, Episodic Memory, Working-Memory, Life-Span, Performance, Depression
Pubmed
Web of science
Création de la notice
04/11/2009 12:42
Dernière modification de la notice
20/08/2019 15:10
Données d'usage