Chronic Sialadenitis revealing hepatitis C: a case report.

Détails

ID Serval
serval:BIB_55B56C134A75
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Chronic Sialadenitis revealing hepatitis C: a case report.
Périodique
Medicina Oral
Auteur(s)
Madrid C., Courtois B., Duran D.
ISSN
1137-2834[print], 1137-2834[linking]
Statut éditorial
Publié
Date de publication
10/2004
Volume
9
Numéro
4
Pages
328-332
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
One 53-year-old male was referred with a history of sensitive peripheral neuropathy and Raynaud disease leading to suspect a Sjögren syndrome (SS). Labial salivary gland biopsy shown the classical features of chronic lymphocytic sialadenitis. As clinical and immunologic tests were positive, we conclude to a chronic lymphocytic sialadenitis simulating SS. Enzyme immunoassay and recombinant immunoblot were positive to HCV. Circulating HCV-RNA was detected by PCR. Liver biopsy revealed chronic persistent hepatitis. In one second biopsy, RNA was extracted. PCR amplification and southern blot hybridization for HCV-RNA were performed. After a 8-month treatment by interferon alpha, HCV-RNA was no longer detected in the serum. There was an objective improvement of the Schirmer test. The detection of HCV-RNA in the salivary glands of a Sjögren like syndrome-patient suggests that a direct infection of the salivary glands by HCV could play an important role in the pathogenesis of HCV related sialadenitis.
Mots-clé
Chronic Disease, Hepatitis C/diagnosis, Humans, Male, Middle Aged, Sialadenitis/virology
Pubmed
Création de la notice
28/01/2008 12:55
Dernière modification de la notice
20/08/2019 15:10
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