Effects of renin inhibition in the conscious primate Macaca fascicularis
Détails
ID Serval
serval:BIB_55B5136A0EBB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of renin inhibition in the conscious primate Macaca fascicularis
Périodique
Hypertension
ISSN
0194-911X (Print)
Statut éditorial
Publié
Date de publication
11/1989
Volume
14
Numéro
5
Pages
480-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
Pro-His-Pro-Phe-His-Statine-Ile-Phe-NH2 (R-Pep-27), a potent renin inhibitory peptide, was infused into the conscious, sodium-depleted Macaca fascicularis at doses of 0, 0.1, 1, 4, 16, and 32 micrograms/kg/min for 10 minutes. At all doses greater than 0.1 microgram/kg/min, there was a parallel decrease in mean arterial pressure (MAP), plasma renin activity, and plasma angiotensin II (Ang II) concentration. On the other hand, assays with monoclonal antibodies specific for total renin and active renin demonstrated that the peptide's inhibition of circulating active renin stimulated the release of both. The maximal effective R-Pep-27 dose was approximately 16 micrograms/kg/min, which reduced MAP by an average of 15.8 +/- 1.4 mm Hg (n = 14) and plasma renin activity and plasma Ang II concentration to 3% (n = 9) and 15% (n = 5), respectively, of the pretreatment values. At 0.1 microgram/kg/min, there was no significant decrease in MAP; however, measurement of plasma renin activity showed an average decrease in activity of 42% (n = 3). No significant change in the heart rate was observed at all the doses studied. For comparison, intravenous captopril (400 micrograms/kg bolus) was administered after the MAP of the monkeys had recovered from the peptide experiments, and it reduced MAP by 25.1 +/- 2.4 mm Hg (n = 10) without significantly changing plasma renin activity. As anticipated, injection of angiotensin I (80-160 ng/kg bolus) into sodium-depleted monkeys during peptide infusion caused a transient rise in MAP of 14.8 +/- 5.4 mm Hg (n = 4) above the mean pretreatment value.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Angiotensin I/pharmacology
Angiotensin II/blood/pharmacology
Animals
Blood Pressure/drug effects
Captopril/pharmacology
Diet, Sodium-Restricted
Dose-Response Relationship, Drug
Furosemide/pharmacology
Heart Rate/drug effects
Macaca mulatta
Oligopeptides/adverse effects/*pharmacology
Osmolar Concentration
Renin/*antagonists & inhibitors/blood/pharmacology
Structure-Activity Relationship
Pubmed
Web of science
Création de la notice
05/03/2008 17:39
Dernière modification de la notice
20/08/2019 15:10