Effects of high-yield thrombocytapheresis on the quality of platelet products.

Détails

ID Serval
serval:BIB_55A6B36A8DA8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effects of high-yield thrombocytapheresis on the quality of platelet products.
Périodique
Transfusion
Auteur⸱e⸱s
Julmy F., Ammann R.A., Mansouri Taleghani B., Fontana S., Hirt A., Leibundgut K.
ISSN
0041-1132 (Print)
ISSN-L
0041-1132
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
48
Numéro
3
Pages
442-450
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
BACKGROUND: The steadily increasing demands for single-donor apheresis platelet (PLT) concentrates (APCs) are a challenge to the PLT supply system. Therefore, efforts to improve plateletpheresis yield, allowing apheresis products to be split into 2 or more units, are valuable strategies. No data to demonstrate in vivo transfusion efficacy of these high-yield split-APCs are currently available, however.
STUDY DESIGN AND METHODS: The transfusion efficacy of APCs produced by two apheresis methods involving different harvest and storing procedures and varying PLT yields was investigated. Efficacy measures were the 1-hour percent PLT recovery (PPR(1h)) and the 1-hour corrected count increment (CCI(1h)). In total, 400 APCs, produced with either an Amicus device (Baxter) and stored in PLT additive solution (T-Sol; Amicus method [AM], n = 107) or a Trima device (Gambro) and stored in plasma (Trima method [TM], n = 293), were transfused to 55 children (31 girls; median age, 9.5 years; range, 0.2-18.5 years) with thrombocytopenia due to chemotherapy or aplastic anemia (median, 4 APCs per child; range, 1-68).
RESULTS: Transfusion efficacy was significantly lower for AM-APCs than for TM-APCs (median PPR(1h), 17 and 33%; median CCI(1h), 7.9 and 15.6, respectively; p < 0.001). Reduced transfusion efficacy correlated in a yield-dependent manner with high apheresis PLT yields (> or =6 x 10(11)) for AM-APCs (p < 0.001).
CONCLUSION: Although in vitro validation of AM- and TM-APCs has been performed, only by evaluating transfusion efficacy in vivo did the AM turn out to be not suitable for high-yield thrombocytapheresis. This study recommends the implementation of in vivo transfusion efficacy studies for high-yield APC apheresis donations.
Mots-clé
Adolescent, Anemia, Aplastic/blood, Anemia, Aplastic/therapy, Blood Platelets/cytology, Child, Child, Preschool, Female, Humans, Infant, Male, Platelet Count, Platelet Transfusion/methods, Plateletpheresis/methods, Thrombocytopenia/blood, Thrombocytopenia/therapy, Treatment Outcome
Pubmed
Web of science
Création de la notice
09/11/2014 17:30
Dernière modification de la notice
20/08/2019 14:10
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