Protein energy malnutrition increases arginase activity in monocytes and macrophages.

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Ressource 1Télécharger: BIB_5565EFE706C8.P001.pdf (1095.00 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_5565EFE706C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Protein energy malnutrition increases arginase activity in monocytes and macrophages.
Périodique
Nutrition and Metabolism
Auteur(s)
Corware K., Yardley V., Mack C., Schuster S., Al-Hassi H., Herath S., Bergin P., Modolell M., Munder M., Müller I., Kropf P.
ISSN
1743-7075 (Electronic)
ISSN-L
1743-7075
Statut éditorial
Publié
Date de publication
2014
Volume
11
Numéro
1
Pages
51
Langue
anglais
Résumé
BACKGROUND: Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases.
METHODS: In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated with immunosuppression and increased pathogen replication.
RESULTS: Our results show that monocytes and macrophages are significantly increased in the bone marrow and blood of mice fed on a protein low diet. No alteration in the capacity of bone marrow derived macrophages isolated from malnourished mice to phagocytose particles, to produce the microbicidal molecule nitric oxide and to kill intracellular Leishmania parasites was detected. However, macrophages and monocytes from malnourished mice express significantly more arginase both in vitro and in vivo. Using an experimental model of visceral leishmaniasis, we show that following protein energy malnutrition, the increased parasite burden measured in the spleen of these mice coincided with increased arginase activity and that macrophages provide a more permissive environment for parasite growth.
CONCLUSIONS: Taken together, these results identify a novel mechanism in protein energy malnutrition that might contributes to increased susceptibility to infectious diseases by upregulating arginase activity in myeloid cells.
Mots-clé
Arginase, Macrophages, Monocytes, Nitric oxide, Leishmaniasis
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/12/2014 14:20
Dernière modification de la notice
20/08/2019 15:10
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