Gene regulation in rodent hepatocytes during development, differentiation and disease
Détails
ID Serval
serval:BIB_55255A09885C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Gene regulation in rodent hepatocytes during development, differentiation and disease
Périodique
European Journal of Biochemistry
ISSN
0014-2956 (Print)
Statut éditorial
Publié
Date de publication
09/1993
Volume
216
Numéro
2
Pages
353-60
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep 1
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep 1
Résumé
The expression of genes in the liver is mostly controlled at the transcriptional level and depends on the regulatory interactions between cis-acting sequences and trans-acting molecules. Proximal promoters and distant enhancers in combination with a number of hepatocyte-enriched DNA-binding proteins and general transcription factors interact specifically with these elements and control the expression of liver-specific genes. Hepatocyte-enriched regulatory proteins have been isolated from liver nuclear extracts, characterized, and their corresponding genes have been cloned. These include the hepatocyte nuclear factors 1, 3, 4 (HNF-1,3,4), some members of the CAAAT/enhancer binding protein (C/EBP) family, and D site binding protein (DBP). These factors belong to larger families and are able to form heterodimers, perhaps with the exception of the HNF-3 family, with other members of the same family. Interestingly, the majority of the genes encoding such proteins are themselves regulated at the transcriptional level, although both transcriptional and post-transcriptional events modulate their expression during development, hepatocyte differentiation and disease, suggesting that a transcriptional cascade may play a critical role in mammalian liver development and differentiation.
Mots-clé
Animals
Base Sequence
Cell Differentiation/genetics
*Gene Expression Regulation
Liver/cytology/growth & development/*metabolism
Liver Diseases/*genetics
Molecular Sequence Data
Oligodeoxyribonucleotides
Rodentia
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 9:41
Dernière modification de la notice
20/08/2019 15:09