Expression of neuroectodermal antigens common to melanomas, gliomas, and neuroblastomas. I. Identification by monoclonal anti-melanoma and anti-glioma antibodies.

Détails

ID Serval
serval:BIB_55209119721A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Expression of neuroectodermal antigens common to melanomas, gliomas, and neuroblastomas. I. Identification by monoclonal anti-melanoma and anti-glioma antibodies.
Périodique
Acta Neuropathologica
Auteur(s)
Carrel S., de Tribolet N., Mach J.P.
ISSN
0001-6322 (Print)
ISSN-L
0001-6322
Statut éditorial
Publié
Date de publication
1982
Volume
57
Numéro
2-3
Pages
158-164
Langue
anglais
Résumé
The reactivity spectrum of five different monoclonal anti-melanoma antibodies cross-reacting with gliomas and neuroblastomas and one monoclonal anti-glioma antibody cross-reacting with melanomas and neuroblastomas was investigated. Comparison of the binding activity of these monoclonal antibodies for 11 melanoma, seven glioma, and three neuroblastoma cell lines showed that each of these clones had a different pattern of cross-reactivity. The results indicated that the antigenic determinants detected by these antibodies were not associated with the same antigen and thus suggested the existence of at least six different antigens common to melanomas, gliomas, and neuroblastomas. Since all these tumors are known to derive from cells originating embryologically from the neural crest, it can be assumed that the antigens recognized by our monoclonal antibodies are neuroectodermal differentiation antigens. However, absorption with fetal brain homogenates abolished only the binding of monoclonal anti-glioma antibody, but did not modify the binding of monoclonal anti-melanoma antibodies.
Mots-clé
Animals, Antibodies, Monoclonal, Antibodies, Neoplasm, Antigens, Neoplasm/analysis, Cell Line, Cross Reactions, Epitopes/analysis, Glioma/immunology, Humans, Melanoma/immunology, Neuroblastoma/immunology, Rabbits/immunology
Pubmed
Web of science
Création de la notice
25/04/2013 14:33
Dernière modification de la notice
20/08/2019 15:09
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