Vasopressin dilates the rat carotid artery by stimulating V1 receptors.

Détails

ID Serval
serval:BIB_5488921C785C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Vasopressin dilates the rat carotid artery by stimulating V1 receptors.
Périodique
Journal of Cardiovascular Pharmacology
Auteur⸱e⸱s
Rutschmann B., Evequoz D., Aubert J.F., Brunner H.R., Waeber B.
ISSN
0160-2446
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
32
Numéro
4
Pages
637-641
Langue
anglais
Résumé
The acute effects of various vasopressor agents on the diameter of the common carotid artery were studied in halothane-anesthetized normotensive rats. The animals were infused intravenously for 60 min with equipressor doses of angiotensin II (10 ng/min), the alpha1-stimulant methoxamine (5 microg/min), lysine vasopressin (5 mU/min), or vehicle. The arterial diameter was measured by using a high-resolution ultrasonic echo-tracking device. The three vasoconstrictors increased the carotid artery diameter, but this effect was significantly more pronounced with lysine vasopressin. Even a nonpressor dose of lysine vasopressin (1 mU/min) caused a significant increase in the arterial diameter. The lysine vasopressin-induced vasodilatation could be prevented by the administration of d(CH2)5Tyr(Me)AVP (10 microg, i.v.), a selective V1-vasopressinergic receptor antagonist. These data therefore suggest that a short-term increase in blood pressure induces in rats a distention of the carotid artery. The increase in arterial diameter seems to involve an active mechanism with lysine vasopressin caused by the stimulation of V1-vasopressinergic receptors.
Mots-clé
Angiotensin II, Animals, Arginine Vasopressin, Blood Pressure, Carotid Arteries, Heart Rate, Hormone Antagonists, Infusions, Intravenous, Lysine Vasopressin, Male, Methoxamine, Rats, Rats, Wistar, Receptors, Vasopressin, Vasoconstriction, Vasoconstrictor Agents, Vasodilation
Pubmed
Web of science
Création de la notice
04/03/2009 15:05
Dernière modification de la notice
20/08/2019 14:09
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