Popliteal lymph node assay as a tool to predict drug-induced GvH-like reactions.

Détails

ID Serval
serval:BIB_54853A0C9E33
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Popliteal lymph node assay as a tool to predict drug-induced GvH-like reactions.
Périodique
Developments In Biological Standardization
Auteur⸱e⸱s
Descotes J., Verdier F., Brouland J.P., Patriarca C.
ISSN
0301-5149 (Print)
ISSN-L
0301-5149
Statut éditorial
Publié
Date de publication
1992
Peer-reviewed
Oui
Volume
77
Pages
111-114
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The popliteal lymph node (PLN) assay was proposed to study a panel of drug-induced clinical manifestations, e.g. lupus syndrome, serum sickness-like disease, lymphadenopathy, scleroderma-like reaction, the mechanism of which was suggested as being similar to a graft-versus-host (GvH) reaction, hence the term GvH-like reaction. This assay can readily be performed in either the mouse or rat. The commonest endpoint is PLN weight, but cellularity and lymphocyte-phenotype analysis can also be determined. Experiments so far show that most drugs and chemicals known to induce such complications in man can be detected by the PLN assay and false-positive responses are extremely few. Interestingly, preliminary results indicate that cimetidine, an immuno-enhancing agent, can increase the response to phenytoin, a positive reference compound in the PLN assay. Thus, in addition to predicting those drugs with the capacity to induce GvH-like reactions and investigating the mechanism involved, the PLN assay may also prove useful in the pre-clinical assessment of immunomodulating agents.
Mots-clé
Animals, Drug Evaluation, Preclinical/methods, Drug Interactions, Graft vs Host Reaction, Humans, Immunologic Techniques, Immunophenotyping, Inflammation/chemically induced, Knee, Lymph Nodes/drug effects, Lymph Nodes/pathology, Mice, Predictive Value of Tests, Rats, Toxicology/methods
Pubmed
Web of science
Création de la notice
13/10/2015 8:52
Dernière modification de la notice
20/08/2019 14:09
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