Transient developmental expression of monoamine transporters in the rodent forebrain

Détails

ID Serval
serval:BIB_547972F807D2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Transient developmental expression of monoamine transporters in the rodent forebrain
Périodique
Journal of Comparative Neurology
Auteur(s)
Lebrand  C., Cases  O., Wehrle  R., Blakely  R. D., Edwards  R. H., Gaspar  P.
ISSN
0021-9967 (Print)
Statut éditorial
Publié
Date de publication
11/1998
Volume
401
Numéro
4
Pages
506-24
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 30
Résumé
Neurons in first-order sensory thalamic nuclei have been shown to express functional plasma membrane serotonin (SERT) and vesicular monoamine (VMAT2) transporters during early postnatal development. In the present study, we provide an extensive description of the spatial and the temporal patterns of VMAT2 and SERT expression, during early embryonic development and postnatal life, by using in situ hybridization and immunocytochemistry. VMAT2 and SERT genes are transiently expressed in a wide population of non-monoaminergic neurons in the central and peripheral nervous system with a large overlap in the temporal and spatial pattern of expression of both genes. A selective pattern of expression of both genes was observed in the thalamus with expression limited to the dorsal thalamus and more particularly to primary sensory relay nuclei that convey point to point projection maps. Transient expression of the transporters was also observed in sensory cranial nerves, in the hippocampus, cerebral cortex, septum, and amygdala. VMAT2 and SERT gene expression was not necessarily linked, as some neural populations expressed only VMAT2, while others only contained SERT. Since VMAT2 serves to transport catecholamines besides serotonin, we examined the developmental expression of the plasma membrane dopamine and norepinephrine transporters but found no transient expression of these genes. Despite minor temporal disparities, VMAT2 and SERT extinguished almost simultaneously during the second and third weeks of post-natal life. These expressions did not seem to be dependent on peripheral neural inputs, since monocular enucleations and infraorbital nerve cuts effected on the day of birth, did not modify the period of transporter expression or of extinction.
Mots-clé
Animals Brain Chemistry/physiology Carrier Proteins/genetics/metabolism Cell Membrane/chemistry/metabolism Dopamine Plasma Membrane Transport Proteins Eye Enucleation Gene Expression Regulation, Developmental/physiology Membrane Glycoproteins/*genetics *Membrane Transport Proteins Mice Mice, Inbred C3H/*physiology Nerve Tissue Proteins/genetics/metabolism Neurons, Afferent/chemistry/physiology *Neuropeptides Neurotransmitter Agents/*genetics Norepinephrine Plasma Membrane Transport Proteins Prosencephalon/*chemistry/cytology/physiology RNA, Messenger/analysis Rats Rats, Sprague-Dawley/*physiology Serotonin/genetics/metabolism *Symporters Thalamus/chemistry/cytology/physiology Time Factors Trigeminal Nerve/cytology/physiology Vesicular Biogenic Amine Transport Proteins Vesicular Monoamine Transport Proteins Vision, Monocular/physiology
Pubmed
Web of science
Création de la notice
24/01/2008 14:27
Dernière modification de la notice
20/08/2019 14:09
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