Microglia in development: linking brain wiring to brain environment.
Détails
ID Serval
serval:BIB_54400A56A5C0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Microglia in development: linking brain wiring to brain environment.
Périodique
Neuron glia biology
ISSN
1741-0533 (Electronic)
ISSN-L
1740-925X
Statut éditorial
Publié
Date de publication
02/2011
Peer-reviewed
Oui
Volume
7
Numéro
1
Pages
77-83
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Microglia are enigmatic non-neuronal cells that infiltrate and take up residence in the brain during development and are thought to perform a surveillance function. An established literature has documented how microglia are activated by pathogenic stimuli and how they contribute to and resolve injuries to the brain. However, much less work has been aimed at understanding their function in the uninjured brain. A series of recent in vivo imaging studies shows that microglia in their resting state are highly motile and actively survey their neuronal surroundings. Furthermore, new data suggest that microglia in their resting state are able to phagocytose unwanted synapses and in this way contribute to synaptic pruning and maturation during development. Coupled with their exquisite sensitivity to pathogenic stimuli, these data suggest that microglia form a link that couples changes in brain environment to changes in brain wiring. Here we discuss this hypothesis and propose a model for the role of microglia during development in sculpting brain connectivity.
Mots-clé
Animals, Brain/cytology, Brain/growth & development, Gene Expression Regulation, Developmental/physiology, Humans, Microglia/physiology, Synapses/physiology
Pubmed
Web of science
Création de la notice
18/12/2018 10:56
Dernière modification de la notice
20/08/2019 14:09