What Was I Thinking? Eye-Tracking Experiments Underscore the Bias that Architecture Exerts on Nuclear Grading in Prostate Cancer.

Détails

Ressource 1Télécharger: BIB_5422C50BA5C4.P001.pdf (2674.96 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_5422C50BA5C4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
What Was I Thinking? Eye-Tracking Experiments Underscore the Bias that Architecture Exerts on Nuclear Grading in Prostate Cancer.
Périodique
Plos One
Auteur(s)
Bombari D., Mora B., Schaefer S.C., Mast F.W., Lehr H.A.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2012
Volume
7
Numéro
5
Pages
e38023
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
We previously reported that nuclear grade assignment of prostate carcinomas is subject to a cognitive bias induced by the tumor architecture. Here, we asked whether this bias is mediated by the non-conscious selection of nuclei that "match the expectation" induced by the inadvertent glance at the tumor architecture. 20 pathologists were asked to grade nuclei in high power fields of 20 prostate carcinomas displayed on a computer screen. Unknown to the pathologists, each carcinoma was shown twice, once before a background of a low grade, tubule-rich carcinoma and once before the background of a high grade, solid carcinoma. Eye tracking allowed to identify which nuclei the pathologists fixated during the 8 second projection period. For all 20 pathologists, nuclear grade assignment was significantly biased by tumor architecture. Pathologists tended to fixate on bigger, darker, and more irregular nuclei when those were projected before kigh grade, solid carcinomas than before low grade, tubule-rich carcinomas (and vice versa). However, the morphometric differences of the selected nuclei accounted for only 11% of the architecture-induced bias, suggesting that it can only to a small part be explained by the unconscious fixation on nuclei that "match the expectation". In conclusion, selection of « matching nuclei » represents an unconscious effort to vindicate the gravitation of nuclear grades towards the tumor architecture.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/07/2012 21:17
Dernière modification de la notice
20/08/2019 14:09
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